ArticleFrontiers in aging neuroscience2017
Frequency-Dependent Altered Functional Connections of Default Mode Network in Alzheimer's Disease.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Parcellation-based tractographic modeling of the salience network through meta-analysis.Brain and behavior · 2022Pooled it
- Transcranial pulse stimulation modulates spectral signatures of Alzheimer's disease in the 3×Tg-AD mouse model.Alzheimer's research & therapy · 2026Article
- The striatal compartments, striosome and matrix, are embedded in largely distinct resting-state functional networks.Frontiers in neural circuits · 2025Article
- Connectivity gradients in spontaneous brain activity at multiple frequency bands.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The relevance of the unique anatomy of the human prefrontal operculum to the emergence of speech.Communications biology · 2023Article
- Frequency dependent whole-brain coactivation patterns analysis in Alzheimer's disease.Frontiers in neuroscience · 2023Article
- The atypical functional connectivity of Broca's area at multiple frequency bands in autism spectrum disorder.Brain imaging and behavior · 2022Article
- Frequency-specific alterations in intrinsic low-frequency oscillations in newly diagnosed male patients with obstructive sleep apnea.Frontiers in neuroscience · 2022Article
- Effect of education on functional network edge efficiency in Alzheimer's disease.Scientific reports · 2021Article
- Time-Frequency Characterization of Resting Brain in Bipolar Disorder during Euthymia-A Preliminary Study.Brain sciences · 2021Article
- Gut microbiota interacts with intrinsic brain activity of patients with amnestic mild cognitive impairment.CNS neuroscience & therapeutics · 2021Article
- Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline.Frontiers in aging neuroscience · 2021Article
- Frequency-Resolved Functional Connectivity: Role of Delay and the Strength of Connections.Frontiers in neural circuits · 2021Article
- Application of Structural and Functional Connectome Mismatch for Classification and Individualized Therapy in Alzheimer Disease.Frontiers in public health · 2020Article
- Changes in Brain Function Networks in Patients With Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study.Frontiers in neurology · 2020Article
- Higher Sensitivity and Reproducibility of Wavelet-Based Amplitude of Resting-State fMRI.Frontiers in neuroscience · 2020Article
- Article
- Resting state network modularity along the prodromal late onset Alzheimer's disease continuum.NeuroImage. Clinical · 2019Article
- A Connectomic Atlas of the Human Cerebrum-Chapter 5: The Insula and Opercular Cortex.Operative neurosurgery (Hagerstown, Md.) · 2018Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder associated with the progressive dysfunction of cognitive ability. Previous research has indicated that the default mode network (DMN) is closely related to cognition and is impaired in Alzheimer's disease. Because recent studies have shown that different frequency bands represent specific physiological functions, DMN functional connectivity studies of the different frequency bands based on resting state fMRI (RS-fMRI) data may provide new insight into AD pathophysiology. In this study, we explored the functional connectivity based on well-defined DMN regions of interest (ROIs) from the five frequency bands: slow-5 (0.01-0.027 Hz), slow-4 (0.027-0.073 Hz), slow-3 (0.073-0.198 Hz), slow-2 (0.198-0.25 Hzs) and standard low-frequency oscillations (LFO) (0.01-0.08 Hz). We found that the altered functional connectivity patterns are mainly in the frequency band of slow-5 and slow-4 and that the decreased connections are long distance, but some relatively short connections are increased. In addition, the altered functional connections of the DMN in AD are frequency dependent and differ between the slow-5 and slow-4 bands. Mini-Mental State Examination scores were significantly correlated with the altered functional connectivity patterns in the slow-5 and slow-4 bands. These results indicate that frequency-dependent functional connectivity changes might provide potential biomarkers for AD pathophysiology.
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