ArticleFrontiers in human neuroscience2017
Microstructural Changes of the Human Brain from Early to Mid-Adulthood.
Article in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Distinct alterations in white matter properties and organization related to maternal treatment initiation in neonates exposed to HIV but uninfected.Scientific reports · 2024Article
- Distinct alterations in white matter properties and organization related to maternal treatment initiation in neonates exposed to HIV but uninfected.bioRxiv : the preprint server for biology · 2024Article
- Central nervous system involvement in chronic inflammatory demyelinating polyradiculoneuropathy-MRS and DTI study.Frontiers in neurology · 2024Article
- Temporal Diffusion Ratio (TDR) for imaging restricted diffusion: Optimisation and pre-clinical demonstration.NeuroImage · 2023Article
- Machine learning-based prediction of motor status in glioma patients using diffusion MRI metrics along the corticospinal tract.Brain communications · 2022Article
- Distinct Age-Specific Effects on Olfactory Associative Learning in C57BL/6 Substrains.Frontiers in behavioral neuroscience · 2022Article
- Gradient Patterns of Age-Related Diffusivity Changes in Cerebral White Matter.Frontiers in neurology · 2022Article
- Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study.Frontiers in psychiatry · 2020Article
- [A review on brain age prediction in brain ageing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Review
- Region-Specific Differences in Morphometric Features and Synaptic Colocalization of Astrocytes During Development.Neuroscience · 2019Article
- Toward a Neuroscience of Adult Cognitive Developmental Theory.Frontiers in neuroscience · 2018Article
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2 authors.
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Abstract
Despite numerous studies on the microstructural changes of the human brain throughout life, we have indeed little direct knowledge about the changes from early to mid-adulthood. The aim of this study was to investigate the microstructural changes of the human brain from early to mid-adulthood. We performed two sets of analyses based on the diffusion tensor imaging (DTI) data of 111 adults aged 18-55 years. Specifically, we first correlated age with skeletonized fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) at global and regional level, and then estimated individuals' ages based on each DTI metric using elastic net, a kind of multivariate pattern analysis (MVPA) method that aims at selecting the model that achieves the best trade-off between goodness of fit and model complexity. We observed statistically significant negative age-vs-FA correlations and relatively less changes of MD. The negative age-vs-FA correlations were associated with negative age-vs-AD and positive age-vs-RD correlations. Regional negative age-vs-FA correlations were observed in the bilateral genu of the corpus callosum (CCg), the corticospinal tract (CST), the fornix and several other tracts, and these negative correlations may indicate the earlier changes of the fibers with aging. In brain age estimation, the chronological-vs-estimated-age correlations based on FA, MD, AD and RD were
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