ReviewFrontiers in neuroanatomy2017
Pseudotyped Lentiviral Vectors for Retrograde Gene Delivery into Target Brain Regions.
Review in Frontiers in neuroanatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Retrograde transduction of dopaminergic cells in substantia nigra of the rhesus monkey.Scientific reports · 2026Article
- Retrograde transduction of dopaminergic cells in substantia nigra of rhesus monkey.bioRxiv : the preprint server for biology · 2026Article
- Selective Neural Pathway Targeting by Using Lentiviral Vectors.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Production and Purification of Lentiviral Vectors.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Lentiviral Vector Administration into the Mouse Brain.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Properties and Application of Pseudotyped Lentiviral Vectors.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Optogenetic Approach for In Vivo Manipulation of Neural Circuits Using Lentiviral Vectors.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Tracing of specific neural pathways in the rat brain using lentiviral vectors for retrograde gene transfer.Anatomical science international · 2025Article
- From thought to action: The organization of spinal projecting neurons.Cell reports · 2025Review
- Progress in Pseudotyping Lentiviral Vectors Towards Cell-Specific Gene Delivery In Vivo.Viruses · 2025Review
- Brain-wide TVA compensation allows rabies virus to retrograde target cell-type-specific projection neurons.Molecular brain · 2022Article
- Double viral vector technology for selective manipulation of neural pathways with higher level of efficiency and safety.Gene therapy · 2021Article
- Targeting herpes simplex virus with CRISPR-Cas9 cures herpetic stromal keratitis in mice.Nature biotechnology · 2021Article
- Maximizing lentiviral vector gene transfer in the CNS.Gene therapy · 2021Article
- AAV9-Retro mediates efficient transduction with axon terminal absorption and blood-brain barrier transportation.Molecular brain · 2020Article
- Viral vectors for neuronal cell type-specific visualization and manipulations.Current opinion in neurobiology · 2020Review
- Dynamic Interaction between Cortico-Brainstem Pathways during Training-Induced Recovery in Stroke Model Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Lentiviral Vector Pseudotyped by Modified Rabies Glycoprotein Does Not Cause Reactive Gliosis and Neurodegeneration in Rat HippocampusIranian biomedical journal · 2019Article
- GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice.Scientific reports · 2019Article
- Emerging role of viral vectors for circuit-specific gene interrogation and manipulation in rodent brain.Pharmacology, biochemistry, and behavior · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene transfer through retrograde axonal transport of viral vectors offers a substantial advantage for analyzing roles of specific neuronal pathways or cell types forming complex neural networks. This genetic approach may also be useful in gene therapy trials by enabling delivery of transgenes into a target brain region distant from the injection site of the vectors. Pseudotyping of a lentiviral vector based on human immunodeficiency virus type 1 (HIV-1) with various fusion envelope glycoproteins composed of different combinations of rabies virus glycoprotein (RV-G) and vesicular stomatitis virus glycoprotein (VSV-G) enhances the efficiency of retrograde gene transfer in both rodent and nonhuman primate brains. The most recently developed lentiviral vector is a pseudotype with fusion glycoprotein type E (FuG-E), which demonstrates highly efficient retrograde gene transfer in the brain. The FuG-E-pseudotyped vector permits powerful experimental strategies for more precisely investigating the mechanisms underlying various brain functions. It also contributes to the development of new gene therapy approaches for neurodegenerative disorders, such as Parkinson's disease, by delivering genes required for survival and protection into specific neuronal populations. In this review article, we report the properties of the FuG-E-pseudotyped vector, and we describe the application of the vector to neural circuit analysis and the potential use of the FuG-E vector in gene therapy for Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.