ArticleFrontiers in neural circuits2017
TDat: An Efficient Platform for Processing Petabyte-Scale Whole-Brain Volumetric Images.
Article in Frontiers in neural circuits, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed.
- Three-color high-definition whole-brain imaging: simultaneous analysis of multiple anatomical structures with colocalized cytoarchitectural information.Biomedical optics express · 2026Article
- A Million-Scale, Difficulty-Stratified Optical-Microscopy Image Annotation for Neuron Reconstruction.Scientific data · 2026Article
- A Fluorescence Imaging-Based 3D Analysis Pipeline for Mouse Trigeminal Ganglion Neurons.Biosensors · 2026Article
- Convergent and Divergent Connectivity Patterns of the Arcuate Fasciculus in Macaques and Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Molecularly defined cellular atlas of the entire mouse brain with isotropic single-cell resolution.Nature communications · 2025Article
- A dorsal subiculum-medial mammillary body pathway for spatial memory.Molecular psychiatry · 2025Article
- A whole-brain male mouse atlas of long-range inputs to histaminergic neurons.Nature communications · 2025Article
- Image enhancement network based on fiber topology-preserving multi-module fusion for neuron reconstruction.Biomedical optics express · 2025Article
- Generation of a High-Precision Whole Liver Panorama and Cross-Scale 3D Pathological Analysis for Hepatic Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Brain-wide 3D neuron detection and mapping with deep learning.Neurophotonics · 2025Article
- A neuronal imaging dataset for deep learning in the reconstruction of single-neuron axons.Frontiers in neuroinformatics · 2025Article
- Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew.eNeuro · 2024Article
- A hierarchically annotated dataset drives tangled filament recognition in digital neuron reconstruction.Patterns (New York, N.Y.) · 2024Article
- Precise reconstruction of the entire mouse kidney at cellular resolution.Biomedical optics express · 2024Article
- Whole-brain mapping of histaminergic projections in mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Multi-perspective label based deep learning framework for cerebral vasculature segmentation in whole-brain fluorescence images.Biomedical optics express · 2022Article
- Whole-Brain Direct Inputs to and Axonal Projections from Excitatory and Inhibitory Neurons in the Mouse Primary Auditory Area.Neuroscience bulletin · 2022Article
- Smart imaging to empower brain-wide neuroscience at single-cell levels.Brain informatics · 2022Review
- Multiscale reconstruction of various vessels in the intact murine liver lobe.Communications biology · 2022Article
- Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer's disease.Nature communications · 2022Article
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11 authors.
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Abstract
Three-dimensional imaging of whole mammalian brains at single-neuron resolution has generated terabyte (TB)- and even petabyte (PB)-sized datasets. Due to their size, processing these massive image datasets can be hindered by the computer hardware and software typically found in biological laboratories. To fill this gap, we have developed an efficient platform named TDat, which adopts a novel data reformatting strategy by reading cuboid data and employing parallel computing. In data reformatting, TDat is more efficient than any other software. In data accessing, we adopted parallelization to fully explore the capability for data transmission in computers. We applied TDat in large-volume data rigid registration and neuron tracing in whole-brain data with single-neuron resolution, which has never been demonstrated in other studies. We also showed its compatibility with various computing platforms, image processing software and imaging systems.
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