Evidence map›Paper›PMID 28824166›Full record

ArticleNature communications2017

CLEC5A is a critical receptor in innate immunity against Listeria infection.

Szu-Ting Chen, Fei-Ju Li, Tzy-Yun Hsu, Shu-Mei Liang, Yi-Chen Yeh, Wen-Yu Liao, Teh-Ying Chou, Nien-Jun Chen, Michael Hsiao, Wen-Bin Yang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
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  5. The role of DAP12 in immune-related inflammatory diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
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  15. Recent Advances in Host Immune Mechanisms AgainstJournal of inflammation research · 2025
    Review
  16. The C-Type Lectin Receptors.Advances in experimental medicine and biology · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Szu-Ting ChenInstitute of Clinical Medicine, National Yang-Ming University, 155 Li-Nong Street, Section 2, Beitou, Taipei, 112, Taiwan.
Fei-Ju LiInstitute of Clinical Medicine, National Yang-Ming University, 155 Li-Nong Street, Section 2, Beitou, Taipei, 112, Taiwan.
Tzy-Yun HsuGenomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.
Shu-Mei LiangGenomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.
Yi-Chen YehDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, 201 Shipai Road, Section 2, Beitou, Taipei, 112, Taiwan.
Wen-Yu LiaoGenomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.
Teh-Ying ChouInstitute of Clinical Medicine, National Yang-Ming University, 155 Li-Nong Street, Section 2, Beitou, Taipei, 112, Taiwan.
Nien-Jun ChenGenome Research Center, National Yang-Ming University, 155 Li-Nong Street, Section 2, Beitou, Taipei, 112, Taiwan.
Michael HsiaoGenomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.
Wen-Bin YangGenomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.
Shie-Liang HsiehInstitute of Clinical Medicine, National Yang-Ming University, 155 Li-Nong Street, Section 2, Beitou, Taipei, 112, Taiwan. slhsieh@gate.sinica.edu.tw.
Genomics Research Center, Academia Sinica · TWNational Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TWAgricultural Biotechnology Research Center, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The C-type lectin member 5A (CLEC5A) is a pattern recognition receptor for members of the Flavivirus family and has critical functions in response to dengue virus and Japanese encephalitis virus. Here we show that CLEC5A is involved in neutrophil extracellular trap formation and the production of reactive oxygen species and proinflammatory cytokines in response to Listeria monocytogenes. Inoculation of Clec5a

Indexed as

AnimalsCytokinesExtracellular TrapsHost-Pathogen InteractionsImmunity, InnateInflammation MediatorsLectins, C-TypeListeria monocytogenesListeriosisMice, Inbred C57BLMice, KnockoutReactive Oxygen SpeciesReceptors, Cell SurfaceClec5a protein, mouseCytokinesInflammation MediatorsLectins, C-TypeReactive Oxygen SpeciesReceptors, Cell Surface

Identifiers

PMID28824166
PMCPMC5563510
OpenAlexW2743526070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.