Evidence map›Paper›PMID 28823762›Full record

ReviewBlood reviews2018

Placenta growth factor mediated gene regulation in sickle cell disease.

Vijay K Kalra, Shuxiao Zhang, Punam Malik, Stanley M Tahara

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Blood reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Interleukin-6 in pregnancy with sickle cell disease.Hematology, transfusion and cell therapy
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vijay K KalraDepartments of Biochemistry and Molecular Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address: vkalra@usc.edu.
Shuxiao ZhangDepartments of Biochemistry and Molecular Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address: shuxiao@usc.edu.
Punam MalikDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Punam.Malik@cchmc.org.
Stanley M TaharaMolecular Microbiology and Immunology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address: stahara@usc.edu.
University of Southern California · USCincinnati Children's Hospital Medical Center · US

Funding

Role of Placenta Growth factor in Sickle ACSR01HL079916 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MALIK, PUNAM · 2005 to 2008
$3.3M
PlGF-HIF1a-miRNA Axis in Sickle Pulmonary HypertensionR01HL111372 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KALRA, VIJAY K., MALIK, PUNAM · 2012 to 2016
$3.1M
NHLBI NIH HHS R01 HL079916NHLBI NIH HHS R01 HL111372
6 · The paper itself

Abstract

Sickle cell anemia (SCA) is an autosomal recessive disorder caused by mutation in the β-globin gene. Pulmonary hypertension (PH), a complication of SCA, results in severe morbidity and mortality. PH is a multifactorial disease: systemic vasculopathy, pulmonary vasoconstriction, and endothelial dysfunction and remodeling. Placenta growth factor (PlGF), an angiogenic growth factor, elaborated from erythroid cells, has been shown to contribute to inflammation, pulmonary vasoconstriction and airway hyper-responsiveness (AH) in mouse models of sickle cell disease. In this review, we summarize the cell-signaling mechanism(s) by which PlGF regulates the expression of genes involved in inflammation, PH and AH in cell culture and corroborate these findings in mouse models of SCA and in individuals with SCA. The role of microRNAs (miRNAs) in the post-transcriptional regulation of these genes is presented and how these miRNAs located in their host genes are transcriptionally regulated. An understanding of the transcriptional regulation of these miRNAs provides a new therapeutic approach to ameliorate the clinical manifestations of SCA.

Indexed as

Gene Expression RegulationAnemia, Sickle CellAnimalsbeta-GlobinsBiomarkersCytokinesHumansHypertension, PulmonaryHypoxia-Inducible Factor 1, alpha SubunitInflammation MediatorsMicroRNAsPlacenta Growth FactorPPAR alphaRNA Processing, Post-TranscriptionalTranscription Factorsbeta-GlobinsBiomarkersCytokinesHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitInflammation MediatorsMicroRNAsPlacenta Growth FactorPPAR alphaTranscription FactorsHypoxia-inducible factormicroRNAsPlacenta growth factorPulmonary hypertensionSickle cell anemiaTranscriptional and post-transcriptional regulation

Identifiers

PMID28823762
PMCPMC5815962
OpenAlexW2746375148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.