ArticleNeuron2017
Suppression of Ventral Hippocampal Output Impairs Integrated Orbitofrontal Encoding of Task Structure.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 112 citations in OpenAlex.
- Interactions between human orbitofrontal cortex and hippocampus support model-based inference.PLoS biology · 2020Trial
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Hippocampal engrams configure prefrontal context representations to guide flexible decisions.bioRxiv : the preprint server for biology · 2026Article
- Building Goal-Directed Cognitive Graphs.bioRxiv : the preprint server for biology · 2026Article
- Cognitive training shapes brain plasticity and schematic representations.Behavioral and brain functions : BBF · 2025Review
- Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit.Nature communications · 2025Article
- Hippocampal output suppresses orbitofrontal cortex schema cell formation.Nature neuroscience · 2025Article
- The medial and lateral orbitofrontal cortex jointly represent the cognitive map of task space.Communications biology · 2025Article
- Hidden state inference requires abstract contextual representations in the ventral hippocampus.Science (New York, N.Y.) · 2024Article
- Prior cocaine use diminishes encoding of latent information by orbitofrontal, but not medial, prefrontal ensembles.Current biology : CB · 2024Article
- Expectancy-related changes in firing of dopamine neurons depend on hippocampus.Nature communications · 2024Article
- Cracking and Packing Information about the Features of Expected Rewards in the Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Optogenetic Inhibition of Rat Anterior Cingulate Cortex Impairs the Ability to Initiate and Stay on Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Offline orbitofrontal cortex reactivation depends on recency of place-reward changes and coheres with hippocampal replay.iScience · 2024Article
- Dissociable contributions of the hippocampus and orbitofrontal cortex to representing task space in a social context.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A goal pointer for a cognitive map in the orbitofrontal cortex.Current opinion in neurobiology · 2023Review
- Total sleep deprivation reduces the table tennis anticipation performance of young men: A functional magnetic resonance imaging study.iScience · 2023Article
- Memory reactivation and suppression modulate integration of the semantic features of related memories in hippocampus.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Generalization of cognitive maps across space and time.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The hippocampus and orbitofrontal cortex (OFC) both make important contributions to decision making and other cognitive processes. However, despite anatomical links between the two, few studies have tested the importance of hippocampal-OFC interactions. Here, we recorded OFC neurons in rats performing a decision making task while suppressing activity in a key hippocampal output region, the ventral subiculum. OFC neurons encoded information about expected outcomes and rats' responses. With hippocampal output suppressed, rats were slower to adapt to changes in reward contingency, and OFC encoding of response information was strongly attenuated. In addition, ventral subiculum inactivation prevented OFC neurons from integrating information about features of outcomes to form holistic representations of the outcomes available in specific trial blocks. These data suggest that the hippocampus contributes to OFC encoding of both concrete, low-level features of expected outcomes, and abstract, inferred properties of the structure of the world, such as task state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.