Evidence map›Paper›PMID 28823720›Full record

Trial reportSchizophrenia research2019

Compensatory cognitive training for people with severe mental illnesses in supported employment: A randomized controlled trial.

Elizabeth W Twamley, Kelsey R Thomas, Cynthia Z Burton, Lea Vella, Dilip V Jeste, Robert K Heaton, Susan R McGurk

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04551027 (Assessing the Effect of Compensatory Cognitive Intervention for Functional Capacity, Cognitive Functions and Severity of Symptoms Among People With Severe Mental Illness), which is not on this map. Cited by 36 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04551027 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Assessing the Effect of Compensatory Cognitive Intervention for Functional Capacity, Cognitive Functions and Severity of Symptoms Among People With Severe Mental Illness

TypeinterventionalSponsorShalvata Mental Health CenterRan2020 to 2021Enrolled60ConditionsMood Disorders, Schizophrenia, Schizoaffective DisorderArmscompensatory cognitive treatment
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  4. Interventions to improve return to work in depressed people.The Cochrane database of systematic reviews · 2020
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  19. Individual placement and support: History, current status, and future directions.PCN reports : psychiatry and clinical neurosciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth W TwamleyDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, 3350 La Jolla Village Drive (116A), San Diego, CA 92161, USA. Electronic address: etwamley@ucsd.edu.
Kelsey R ThomasDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA; VA San Diego Healthcare System, 3350 La Jolla Village Drive (116B), San Diego, CA 92161, USA.
Cynthia Z BurtonDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA; Department of Psychiatry, University of Michigan, 4250 Plymouth Rd., Ann Arbor, MI 48109, USA.
Lea VellaDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA; VA San Francisco Healthcare System, 4150 Clement Street, San Francisco, CA 94121, USA.
Dilip V JesteDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA.
Robert K HeatonDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA.
Susan R McGurkDepartment of Occupational Therapy and Center for Psychiatric Rehabilitation, Boston University, 940 Commonwealth Avenue West, Boston, MA 02215, USA.

Funding

FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Cognitive Training to Improve Work Outcomes in Severe Mental IllnessR01MH080150 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TWAMLEY, ELIZABETH W · 2008 to 2012
$1.4M
NIMH NIH HHS R01 MH080150NIMH NIH HHS T32 MH018399NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

Treatments for cognitive and functional impairments associated with severe mental illnesses are urgently needed. We tested a 12-week, manualized, Compensatory Cognitive Training (CCT) intervention targeting prospective memory, attention, learning/memory, and executive functioning in the context of supported employment for people with severe mental illnesses who were seeking work. 153 unemployed, work-seeking outpatients with schizophrenia/schizoaffective disorder (n=58), bipolar disorder (n=37), or major depression (n=58) were randomized to receive supported employment plus CCT or enhanced supported employment, a robust control group. Assessments of neuropsychological performance, functional capacity, psychiatric symptom severity, and self-reported functioning and quality of life were administered at baseline and multiple follow-up assessments over two years; work outcomes were collected for two years. Forty-seven percent of the participants obtained competitive work, but there were no differences in work attainment, weeks worked, or wages earned between the CCT and the enhanced supported employment group. ANCOVAs assessing immediate post-treatment effects demonstrated significant, medium to large, CCT-associated improvements on measures of working memory (p=0.038), depressive symptom severity (p=0.023), and quality of life (p=0.003). Longer-term results revealed no statistically significant CCT-associated improvements, but a trend (p=0.058) toward a small to medium CCT-associated improvement in learning. Diagnostic group (schizophrenia-spectrum vs. mood disorder) did not affect outcomes. We conclude that CCT has the potential to improve cognitive performance, psychiatric symptom severity, and quality of life in people with severe mental illnesses. Receiving CCT did not result in better work outcomes, suggesting that supported employment can result in competitive work regardless of cognitive status.

Indexed as

Employment, SupportedAdultBipolar DisorderCognitive DysfunctionCognitive RemediationFemaleHumansMajor Depressive DisorderMaleMiddle AgedOutcome Assessment, Health CarePsychiatric RehabilitationPsychotic DisordersSchizophreniaBipolar disorderCognitionFunctioningMajor depressive disorderRehabilitationSchizophrenia

Identifiers

PMID28823720
PMCPMC5816728

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.