Evidence map›Paper›PMID 28823596›Full record

ReviewMolecular aspects of medicine2018

High-dimension single-cell analysis applied to cancer.

Lili Wang, Kenneth J Livak, Catherine J Wu

Abstract readReview
In one paragraph

Review in Molecular aspects of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Single-Cell Analysis in Immuno-Oncology.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lili WangDana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: Lilwang@coh.org.
Kenneth J LivakDana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: ken.livak@gmail.com.
Catherine J WuDana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: cwu@partners.org.

Funding

ProteomicsP01CA206978 · NCI · DANA-FARBER CANCER INST · PI WU, CATHERINE JU-YING · 2016 to 2025
$17.0M
ITSC for Leukemia: Novel Molecular Strategies for NCTN: "Individualized" TherapieU10CA180861 · NCI · OHIO STATE UNIVERSITY · PI BLOOMFIELD, CLARA D, MARCUCCI, GUIDO · 2014 to 2018
$3.4M
Statistical methods for analysis of single-cell variabilityR01HL131768 · NHLBI · HARVARD MEDICAL SCHOOL · PI KHARCHENKO, PETER V · 2015 to 2019
$2.4M
(PQD1) lmpact of cytotoxic and targeted therapy on clonal evolution of CLLR01CA184922 · NCI · DANA-FARBER CANCER INST · PI WU, CATHERINE JU-YING · 2014 to 2017
$2.2M
Defining the impact of clonal evolution on chronic lymphocytic leukemiaR01CA182461 · NCI · DANA-FARBER CANCER INST · PI WU, CATHERINE JU-YING · 2014 to 2018
$1.8M
Single-cell analysis of tumor-microenvironment interactions in follicular lymphomaR21CA220147 · NCI · HARVARD MEDICAL SCHOOL · PI KHARCHENKO, PETER V, WU, CATHERINE JU-YING · 2017 to 2019
$424k
NCI NIH HHS P01 CA206978NCI NIH HHS R01 CA182461NCI NIH HHS R01 CA184922NCI NIH HHS R21 CA220147NCI NIH HHS U10 CA180861NHLBI NIH HHS R01 HL131768
6 · The paper itself

Abstract

High-dimension single-cell technology is transforming our ability to study and understand cancer. Numerous studies and reviews have reported advances in technology development. The biological insights gleaned from single-cell technology about cancer biology are less reviewed. Here we focus on research studies that illustrate novel aspects of cancer biology that bulk analysis could not achieve, and discuss the fresh insights gained from the application of single-cell technology across basic and clinical cancer studies.

Indexed as

EcosystemHumansNeoplasmsPhylogenySingle-Cell AnalysisCell identityCorrelation analysisSingle-cell analysisSubclone phylogenyTumor ecosystemTumor heterogeneity

Identifiers

PMID28823596
PMCPMC5780229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.