Evidence map›Paper›PMID 28823557›Full record

ArticleCell2017

Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.

Elizabeth Y Qin, Dominique D Cooper, Keene L Abbott, James Lennon, Surya Nagaraja, Alan Mackay, Chris Jones, Hannes Vogel, Peter K Jackson, Michelle Monje

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 1 synthesis or guideline pooled it, 234 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  14. Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma.bioRxiv : the preprint server for biology · 2025
    Article
  15. Review
  16. Article
  17. Neuro-Cancer Interactions Shape Glioma Intratumoral Heterogeneity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  18. Article
  19. Article
  20. Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Elizabeth Y QinDepartment of Neurology, Stanford University, Palo Alto, CA 94305, USA.
Dominique D CooperDepartment of Neurology, Stanford University, Palo Alto, CA 94305, USA.
Keene L AbbottBaxter Laboratory, Department of Microbiology & Immunology, Stanford University, Palo Alto, CA 94305, USA.
James LennonDepartment of Neurology, Stanford University, Palo Alto, CA 94305, USA.
Surya NagarajaDepartment of Neurology, Stanford University, Palo Alto, CA 94305, USA.
Alan MackayDivisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.
Chris JonesDivisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.
Hannes VogelDepartment of Neurology, Stanford University, Palo Alto, CA 94305, USA; Department of Pathology, Stanford University, Palo Alto, CA 94305, USA; Department of Neurosurgery, Stanford University, Palo Alto, CA 94305, USA; Department of Pediatrics, Stanford University, Palo Alto, CA 94305, USA.
Peter K JacksonBaxter Laboratory, Department of Microbiology & Immunology, Stanford University, Palo Alto, CA 94305, USA; Department of Pathology, Stanford University, Palo Alto, CA 94305, USA.
Michelle MonjeDepartment of Neurology, Stanford University, Palo Alto, CA 94305, USA; Department of Pathology, Stanford University, Palo Alto, CA 94305, USA; Department of Neurosurgery, Stanford University, Palo Alto, CA 94305, USA; Department of Pediatrics, Stanford University, Palo Alto, CA 94305, USA. Electronic address: mmonje@stanford.edu.
Palo Alto University · USBaxter (United States) · USInstitute of Cancer Research · GBStanford University · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Neuronal activity-regulated mechanisms of glioma growthR01NS092597 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2016 to 2021
$2.1M
Cancer Research UK 13982Cancer Research UK 23536NCI NIH HHS P30 CA124435NINDS NIH HHS R01 NS092597
6 · The paper itself

Abstract

The lateral ventricle subventricular zone (SVZ) is a frequent and consequential site of pediatric and adult glioma spread, but the cellular and molecular mechanisms mediating this are poorly understood. We demonstrate that neural precursor cell (NPC):glioma cell communication underpins this propensity of glioma to colonize the SVZ through secretion of chemoattractant signals toward which glioma cells home. Biochemical, proteomic, and functional analyses of SVZ NPC-secreted factors revealed the neurite outgrowth-promoting factor pleiotrophin, along with required binding partners SPARC/SPARCL1 and HSP90B, as key mediators of this chemoattractant effect. Pleiotrophin expression is strongly enriched in the SVZ, and pleiotrophin knock down starkly reduced glioma invasion of the SVZ in the murine brain. Pleiotrophin, in complex with the binding partners, activated glioma Rho/ROCK signaling, and ROCK inhibition decreased invasion toward SVZ NPC-secreted factors. These findings demonstrate a pathogenic role for NPC:glioma interactions and potential therapeutic targets to limit glioma invasion. PAPERCLIP.

Indexed as

AgedAnimalsBrain NeoplasmsCarrier ProteinsCell CommunicationChildCytokinesDrug Delivery SystemsFemaleGliomaHeterograftsHSP90 Heat-Shock ProteinsHumansLateral VentriclesMaleMiceCarrier ProteinsCytokinesHSP90 Heat-Shock Proteinspleiotrophinrho GTP-Binding Proteinsdiffuse intrinsic pontine gliomaglioblastomaHSP90invasionneural precursor cellpleiotrophinSPARCSPARCL1subventricular zone

Identifiers

PMID28823557
PMCPMC5587159
OpenAlexW2749856153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.