ArticleCell2017
Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories.
Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers.
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Who cites it
176 citing papers in PubMed, 309 citations in OpenAlex.
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- Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging.Human brain mapping · 2021Trial
- Hippocampal circuits underlie improvements in self-reported anxiety following mindfulness training.Brain and behavior · 2020Trial
- Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.Current research in neurobiology · 2026Article
- GABAergic subiculum-medial entorhinal projection in mice and rats.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Prefrontal-raphe-habenular circuit drives fear memory recall and updating.Nature communications · 2026Article
- Subicular plateaus signal reward locations during goal-directed behavior.Cell reports · 2026Article
- Exposure to broadband noise during non-REM sleep impairs hippocampal sharp-wave ripples and memory consolidation.Current biology : CB · 2026Article
- Dysfunction of hippocampal cells and its role in cognitive impairment.Neural regeneration research · 2026Article
- Fibronectin1-Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Hippocampal CA2 modulates trace fear conditioning through circuit-specific control of CA1.bioRxiv : the preprint server for biology · 2026Article
- Simultaneous brain-wide single-cell recording resolves spatiotemporal memory architecture.bioRxiv : the preprint server for biology · 2026Article
- Encoding Patterned Spatial Behavior in the Subiculum.Hippocampus · 2026Review
- [Electroacupuncture at Baihui and Zusanli improves fear memory extinction in single prolonged stress mice by activating hippocampal astrocytes].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Response dynamics of discrete subiculum→retrosplenial cortex projections underlying trace fear conditioning.iScience · 2026Article
- Corticotropin-Releasing Factor and Somatostatin Neurons in the Central Amygdala Mediate Dynamic Defensive Behaviors during Fear Extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Multimodal neuroimaging of brain microstructure and hippocampal morphology alterations in type 2 diabetes mellitus.Scientific reports · 2026Article
- Article
- Perinatal exposure to metal mixtures disrupts neuronal function and behavior.Environmental research · 2026Article
116 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The formation and retrieval of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells (engram cells) by a common set of neural circuits, but this hypothesis has not been established. The medial temporal-lobe system is essential for the formation and retrieval of episodic memory for which individual hippocampal subfields and entorhinal cortex layers contribute by carrying out specific functions. One subfield whose function is poorly known is the subiculum. Here, we show that dorsal subiculum and the circuit, CA1 to dorsal subiculum to medial entorhinal cortex layer 5, play a crucial role selectively in the retrieval of episodic memories. Conversely, the direct CA1 to medial entorhinal cortex layer 5 circuit is essential specifically for memory formation. Our data suggest that the subiculum-containing detour loop is dedicated to meet the requirements associated with recall such as rapid memory updating and retrieval-driven instinctive fear responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.