SynthesisClinical autonomic research : official journal of the Clinical Autonomic Research Society2017
The Etiology of Primary Hyperhidrosis: A Systematic Review.
Synthesis in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- How to diagnose and measure primary hyperhidrosis: a systematic review of the literature.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Pooled it
- The comparative study of letibotulinum toxin A and onabotulinum toxin A in treatment of primary axillary hyperhidrosis.Archives of dermatological research · 2025Trial
- A neurocutaneous NaScience advances · 2026Article
- Associations between Primary Hyperhidrosis and Psychiatric Conditions: A Matched Case-Control Study of 8,508 Patients.Skin appendage disorders · 2026Article
- Review
- Prediction of compensatory hyperhidrosis severity after endoscopic thoracic sympathectomy in primary hyperhidrosis patients based on rough set analysis.Journal of thoracic disease · 2026Article
- Microneedling Delivery of Botulinum Toxin Versus Intradermal Injection in the Treatment of Facial Hyperhidrosis.The Journal of clinical and aesthetic dermatology · 2022Article
- Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis.Annals of clinical and translational neurology · 2022Article
- Paeoniflorin inhibits proliferation and promotes autophagy and apoptosis of sweat gland cells.Experimental and therapeutic medicine · 2022Article
- Retroperitoneoscopic lumbar sympathectomy for the treatment of primary plantar hyperhidrosis.BMC surgery · 2021Article
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro.PloS one · 2019Article
- Symptoms of anxiety and depression in patients with primary hyperhidrosis and its association with the result of clinical treatment with oxybutynin.Clinics (Sao Paulo, Brazil)Article
- Infrared thermography in the diagnosis of palmar hyperhidrosis: A diagnostic study.Medical journal, Armed Forces IndiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrimary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Recently some differences between affected and non-affected people have been reported. The aim of this review is to summarize these new etiological data.
methodsSearch of the literature was performed in the PubMed/Medline Database and pertinent articles were retrieved and reviewed. Additional publications were obtained from the references of these articles.
resultsSome anatomical and pathophysiological characteristics (as well as enzymatic, metabolic, and neurological dysfunctions) have been observed in hyperhidrotic subjects; three main possible etiological factors predominate. A familial trait seems to exist, and genetic loci associated with hyperhidrosis have been identified. Histological differences were observed in sympathetic ganglia of hyperhidrotic subjects: the ganglia were larger and contained a higher number of ganglion cells. A higher expression of acetylcholine and alpha-7 neuronal nicotinic receptor subunit in the sympathetic ganglia of patients with hyperhidrosis has been reported.
conclusionsDespite these accumulated data, the etiology of primary hyperhidrosis remains obscure. Nevertheless, three main lines for future research seem to be delineated: genetics, histological observations, and enzymatic studies.
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