ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2017
Methanobrevibacter smithii, a methanogen consistently colonising the newborn stomach.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 63 citations in OpenAlex.
- Altered GABA and secondary bile acids in Guillain-Barré syndrome: association with gut dysbiosis.Frontiers in immunology · 2026Article
- Methanobrevibacter smithii strain U29 whole genome sequence delineates M. smithii intermediate cell variants.BMC research notes · 2025Article
- Human microbiome acquisition and transmission.Nature reviews. Microbiology · 2025Review
- Growth Characteristics of Sheep-DerivedMicroorganisms · 2025Article
- Human Milk Archaea Associated with Neonatal Gut Colonization and Its Co-Occurrence with Bacteria.Microorganisms · 2025Article
- The human milk bacteriome and mycobiome and their inter-kingdom interactions viewed across geography.Frontiers in nutrition · 2025Article
- Review
- Causal effects of gut microbiome on HIV infection: a two-sample mendelian randomization analysis.BMC infectious diseases · 2024Article
- The Role of Methanogenic Archaea in Inflammatory Bowel Disease-A Review.Journal of personalized medicine · 2024Review
- Article
- Microbial Mechanistic Insight into the Role of Yeast-Derived Postbiotics in Improving Sow Reproductive Performance in Late Gestation and Lactation Sows.Animals : an open access journal from MDPI · 2024Article
- Human associated Archaea: a neglected microbiome worth investigating.World journal of microbiology & biotechnology · 2024Review
- Review
- Effect of Antimicrobial Use in Conventional Versus Natural Cattle Feedlots on the Microbiome and Resistome.Microorganisms · 2023Article
- A child is not an adult: development of a new in vitro model of the toddler colon.Applied microbiology and biotechnology · 2022Review
- Rapid identification of clinically interesting methanogens using an improved MALDI-TOF-MS assay.Access microbiology · 2022Article
- Metabolic Synergy between Human SymbiontsMicrobiology spectrum · 2022Article
- A Non-Invasive Neonatal Signature Predicts Later Development of Atopic Diseases.Journal of clinical medicine · 2022Article
- Bacteria and Methanogens in the Human Microbiome: a Review of Syntrophic Interactions.Microbial ecology · 2022Review
- Cultivation of gastrointestinal microbiota in a new growth system revealed dysbiosis and metabolic disruptions in carcinoma-bearing rats.Frontiers in microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methanobrevibacter smithii is the main human methanogen almost always found in the digestive tract of adults. Yet, the age at which M. smithii establishes itself as part of the developing intestinal microflora remains unknown. In order to gain insight into this, we developed a polyphasic approach, including microscopic observation by fluorescence in situ hybridisation, polymerase chain reaction (PCR) sequencing detection, identification and culture, to isolate and genotype M. smithii in one-day-old newborns' gastric juice specimens. In the presence of negative controls, 50/50 (100%) prospectively analysed newborn gastric juice specimens were PCR-positive for methanogens, all identified as M. smithii by sequencing. We succeeded in cultivating M. smithii in 35/50 (70%) newborn gastric juice specimens, while 15/50 specimens remained sterile. Further, M. smithii was observed by direct microscopic investigation using fluorescence in situ hybridisation. Multispacer sequence typing found one of seven different genotypes per specimen, these genotypes having all been previously described in adult human stools. Methanobrevibacter smithii is an early inhabitant of the human stomach, colonising the gastric mucosa just after birth, and the mother's gut microbiota is a probable source of colonisation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.