Evidence map›Paper›PMID 28823093›Full record

ArticleMycopathologia2017

Candida albicans/Staphylococcus aureus Dual-Species Biofilm as a Target for the Combination of Essential Oils and Fluconazole or Mupirocin.

Aleksandra Budzyńska, Sylwia Różalska, Beata Sadowska, Barbara Różalska

Abstract read
In one paragraph

Article in Mycopathologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Recent Advances and Opportunities in the Study ofFrontiers in cellular and infection microbiology · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Journal of fungi (Basel, Switzerland) · 2019
    Review
  17. Article
  18. Chemical Composition and Antimicrobial Effectiveness ofMolecules (Basel, Switzerland) · 2019
    Article
  19. Frontiers in microbiology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aleksandra BudzyńskaLaboratory of Microbiological and Technical Services, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland.
Sylwia RóżalskaDepartment of Industrial Microbiology and Biotechnology, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland.
Beata SadowskaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland.
Barbara RóżalskaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland. barbara.rozalska@biol.uni.lodz.pl.ORCID http://orcid.org/0000-0001-8465-659X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effectiveness of essential oils (EOs), fluconazole (FLU) and mupirocin (MUP) used alone or in combination against mono-species and mixed Candida albicans/Staphylococcus aureus biofilms was examined. An experimentally established dual-species biofilm model, verified by fluorescence microscopy and viable cell counting, was used. Selected commercial EOs were tested: geranium, citronella and clove oils, which have been chemically characterized and found to differ in the content of the main components (qualitative and quantitative). As expected, C. albicans and S. aureus biofilms were less susceptible to fluconazole and mupirocin action, respectively, compared to the planktonic counterparts. However, the drug effectiveness in combination with the EOs was significantly improved, giving enhancement of biofilm eradication than caused by the antibiotics alone. Moreover, dual-species biofilm formation was limited by sub-MIC of EOs, and preformed mixed biofilm was eliminated more efficiently by combined action of drugs and EOs.

Indexed as

Antifungal AgentsBiofilmsCandida albicansClove OilDrug CombinationsFluconazoleGeraniumHyphaeMicrobial Sensitivity TestsMupirocinOils, VolatilePlant OilsStaphylococcus aureusAntifungal Agentscitronella oilClove OilDrug CombinationsFluconazoleMupirocinOils, VolatilePlant OilsDual-species bacterial/fungal biofilmEssential oils

Identifiers

PMID28823093
PMCPMC5684249

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.