ArticleBiomechanics and modeling in mechanobiology2018
Mechanobiological model of arterial growth and remodeling.
Article in Biomechanics and modeling in mechanobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Article
- Multiscale Kinematic Growth Coupled With Mechanosensitive Systems Biology in Open-Source Software.Journal of biomechanical engineering · 2025Article
- Bridging hemodynamics, tissue mechanics, and pathophysiology in coronary artery disease: A new agent-based model with tetrahedral mesh integration.Journal of biomechanics · 2025Article
- Multiscale computational model predicts how environmental changes and treatments affect microvascular remodeling in fibrotic disease.PNAS nexus · 2025Article
- Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- Multiscale computational model predicts how environmental changes and drug treatments affect microvascular remodeling in fibrotic disease.bioRxiv : the preprint server for biology · 2024Article
- Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension.Journal of the mechanical behavior of biomedical materials · 2022Article
- Computational model of damage-induced growth in soft biological tissues considering the mechanobiology of healing.Biomechanics and modeling in mechanobiology · 2021Article
- Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models.Frontiers in bioengineering and biotechnology · 2021Review
- Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress.Frontiers in physiology · 2021Article
- [Review of studies on the biomechanical modelling of the coupling effect between stent degradation and blood vessel remodeling].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Mechanistic evaluation of long-term in-stent restenosis based on models of tissue damage and growth.Biomechanics and modeling in mechanobiology · 2020Article
- Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms.Current opinion in biomedical engineering · 2020Review
- A computational bio-chemo-mechanical model of in vivo tissue-engineered vascular graft development.Integrative biology : quantitative biosciences from nano to macro · 2020Article
- Location-Specific Comparison Between a 3D In-Stent Restenosis Model and Micro-CT and Histology Data from Porcine In Vivo Experiments.Cardiovascular engineering and technology · 2019Article
- Article
- Mathematical modelling of the restenosis process after stent implantation.Journal of the Royal Society, Interface · 2019Article
- Uncertainty Quantification of a Multiscale Model for In-Stent Restenosis.Cardiovascular engineering and technology · 2018Article
- Bio-chemo-mechanics of thoracic aortic aneurysms.Current opinion in biomedical engineering · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A coupled agent-based model (ABM) and finite element analysis (FEA) computational framework is developed to study the interplay of bio-chemo-mechanical factors in blood vessels and their role in maintaining homeostasis. The agent-based model implements the power of REPAST Simphony libraries and adapts its environment for biological simulations. Coupling a continuum-level model (FEA) to a cellular-level model (ABM) has enabled this computational framework to capture the response of blood vessels to increased or decreased levels of growth factors, proteases and other signaling molecules (on the micro scale) as well as altered blood pressure. Performance of the model is assessed by simulating porcine left anterior descending artery under normotensive conditions and transient increases in blood pressure and by analyzing sensitivity of the model to variations in the rule parameters of the ABM. These simulations proved that the model is stable under normotensive conditions and can recover from transient increases in blood pressure. Sensitivity studies revealed that the model is most sensitive to variations in the concentration of growth factors that affect cellular proliferation and regulate extracellular matrix composition (mainly collagen).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.