ArticleInternational journal of legal medicine2018
Age estimation based on aspartic acid racemization in dentine: what about caries-affected teeth?
Article in International journal of legal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Advancing Forensic Human Chronological Age Estimation: Biochemical, Genetic, and Epigenetic Approaches from the Last 15 Years: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Performance of Forensic Age Estimation by Aspartic Acid Racemization and DNA Methylation: A Systematic Review.F1000Research · 2024Pooled it
- Reliability of aspartic acid racemization rate for chronological age estimation-a systematic review and meta-analysis.International journal of legal medicine · 2022Pooled it
- Accuracy and challenges in age estimation in adults: a scoping review of anthropological, dental, biochemical, and molecular methods.Forensic science, medicine, and pathology · 2025Article
- Review
- Analysis ofBiomolecules · 2021Article
- Identifying Methylation Patterns in Dental Pulp Aging: Application to Age-at-Death Estimation in Forensic Anthropology.International journal of molecular sciences · 2021Article
- Age related changes of rib cortical bone matrix and the application to forensic age-at-death estimation.Scientific reports · 2021Article
- Aging and trace elements in human coronal tooth dentine.Scientific reports · 2020Article
- Age estimation based on aspartic acid racemization in caries-affected teeth: need for further explorations.International journal of legal medicine · 2018Article
- Reply to the letter by Kumar and Kanchan "Age estimation based on aspartic acid racemization in cariesaffected teeth: need for further explorations".International journal of legal medicine · 2018Article
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4 authors at 1 institution in 1 country.
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Abstract
Age estimation based on aspartic acid racemization (AAR) in dentine is one of the most precise methods in adult age. Caries induces protein degradation and may have an impact on the kinetics of AAR in dentine. We systematically examined standardized prepared dentine samples from caries-affected teeth to clarify the question, if caries-affected teeth should not be used for age estimation based on AAR at all, or if the analysis of dentine samples from such teeth may be useful after removal of the caries-affected tissue according to clinical standards. Our results suggest that caries may lead to an extensive protein degradation even in macroscopically healthy-appearing dentine samples from caries-affected teeth and may significantly affect the precision of age estimation. To ensure the quality of age estimation based on AAR in forensic practice, we recommend using dentine samples from healthy teeth. If only caries-affected teeth are available, dentine samples from at least two teeth from the same individual should be analyzed as it seems unlikely that caries-induced protein degradation occurred with identical kinetics in two different teeth. In any case, results of the analysis of caries-affected teeth must be interpreted with caution.
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