Evidence map›Paper›PMID 28822839›Full record

ArticleExperimental neurology2017

Decreased surface expression of the δ subunit of the GABA

Nianhui Zhang, Zechun Peng, Xiaoping Tong, A Kerstin Lindemeyer, Yliana Cetina, Christine S Huang, Richard W Olsen, Thomas S Otis, Carolyn R Houser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Altered brain serotonin 5-HTNeuropharmacology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Virally-induced expression of GABAProgress in neurobiology · 2022
    Article
  12. Article
  13. Review
  14. FMRP regulates GABACell reports · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Cortical interneurons in autism.Nature neuroscience · 2021
    Review
  19. Channelopathies in fragile X syndrome.Nature reviews. Neuroscience · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nianhui ZhangDepartment of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.
Zechun PengDepartment of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.
Xiaoping TongDepartment of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.
A Kerstin LindemeyerDepartment of Medical and Molecular Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yliana CetinaDepartment of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.
Christine S HuangDepartment of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.
Richard W OlsenDepartment of Medical and Molecular Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Thomas S OtisDepartment of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Carolyn R HouserDepartment of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: houser@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

GABA Receptors and Hilar Neuron Survival in EpilepsyR01NS075245 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUSER, CAROLYN R · 2012 to 2020
$3.1M
Unique pharmacology of ligand sites on delta subunit-containing GABA-A receptorsR01AA021213 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLSEN, RICHARD W, WALLNER, MARTIN · 2013 to 2019
$1.6M
GABA System Alterations and Fragile X SyndromeR01HD067225 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUSER, CAROLYN R · 2012 to 2016
$1.6M
NIAAA NIH HHS R01 AA021213NICHD NIH HHS R01 HD067225NINDS NIH HHS R01 NS075245
6 · The paper itself

Abstract

While numerous changes in the GABA system have been identified in models of Fragile X Syndrome (FXS), alterations in subunits of the GABA

Indexed as

AnimalsDentate GyrusFragile X SyndromeGene ExpressionMaleMiceMice, Inbred C57BLMice, KnockoutNeural InhibitionOrgan Culture TechniquesProtein SubunitsReceptors, GABA-AProtein SubunitsReceptors, GABA-ADentate gyrusFmr1 geneFragile X mental retardation proteinFragile X syndromeGABA receptorTonic inhibition

Identifiers

PMID28822839
PMCPMC5612918
OpenAlexW2747121279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.