Evidence map›Paper›PMID 28822749›Full record

ArticleNeuroImage2019

Dominance of layer-specific microvessel dilation in contrast-enhanced high-resolution fMRI: Comparison between hemodynamic spread and vascular architecture with CLARITY.

Alexander John Poplawsky, Mitsuhiro Fukuda, Bok-Man Kang, Jae Hwan Kim, Minah Suh, Seong-Gi Kim

Abstract readComparative Study
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Dissection of brain-wide resting-state and functional somatosensory circuits by fMRI with optogenetic silencing.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Layer-dependent functional connectivity methods.Progress in neurobiology · 2021
    Review
  11. Article
  12. Article
  13. Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Review
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander John PoplawskyNeuroimaging Laboratory, Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Mitsuhiro FukudaNeuroimaging Laboratory, Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: mif5@pitt.edu.
Bok-Man KangCenter for Neuroscience Imaging Research, Institute of Basic Science, Suwon, 440-746, Republic of Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, 440-746, Republic of Korea.
Jae Hwan KimCenter for Neuroscience Imaging Research, Institute of Basic Science, Suwon, 440-746, Republic of Korea.
Minah SuhCenter for Neuroscience Imaging Research, Institute of Basic Science, Suwon, 440-746, Republic of Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, 440-746, Republic of Korea.
Seong-Gi KimCenter for Neuroscience Imaging Research, Institute of Basic Science, Suwon, 440-746, Republic of Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, 440-746, Republic of Korea. Electronic address: seonggikim@skku.edu.

Funding

Neurovascular Mechanisms of Layer-specific fMRIR01EB003324 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FUKUDA, MITSUHIRO · 2003 to 2019
$4.7M
Training in the Neurobiology of Neurodegenerative DiseaseT32NS007391 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZIGMOND, MICHAEL J · 1997 to 2013
$2.3M
TRAINING IN THE NEUROBIOLOGY OF PSYCHIATRIC DISORDERST32MH018273 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZIGMOND, MICHAEL J · 1985 to 2010
$1.8M
Hemodynamic response of excitatory and inhibitory neuronsR21EB018903 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FUKUDA, MITSUHIRO · 2015 to 2016
$413k
NIBIB NIH HHS R01 EB003324NIBIB NIH HHS R21 EB018903NIMH NIH HHS T32 MH018273NINDS NIH HHS T32 NS007391
6 · The paper itself

Abstract

Contrast-enhanced cerebral blood volume-weighted (CBVw) fMRI response peaks are specific to the layer of evoked synaptic activity (Poplawsky et al., 2015), but the spatial resolution limit of CBVw fMRI is unknown. In this study, we measured the laminar spread of the CBVw fMRI evoked response in the external plexiform layer (EPL, 265 ± 65 μm anatomical thickness, mean ± SD, n = 30 locations from 5 rats) of the rat olfactory bulb during electrical stimulation of the lateral olfactory tract and examined its potential vascular source. First, we obtained the evoked CBVw fMRI responses with a 55 × 55 μm

Indexed as

AnimalsHemodynamicsImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeuroimagingOlfactory BulbRatsRats, Sprague-DawleyCapillaryCerebral blood volumeLayer-specific fMRIMIONOlfactory bulbPericyte

Identifiers

PMID28822749
PMCPMC5815958

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.