Trial reportEuropean urology2018
Intravenous Mannitol Versus Placebo During Partial Nephrectomy in Patients with Normal Kidney Function: A Double-blind, Clinically-integrated, Randomized Trial.
Trial report in European urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Effect of intravenous mannitol on renal function in patients undergoing laparoscopic nephron-sparing surgery: a randomized, double-blinded trial.International urology and nephrology · 2025Trial
- Effect of perioperative dexmedetomidine on acute kidney injury after partial nephrectomy: a single-centre, randomised, double-blind, placebo-controlled trial.British journal of anaesthesia · 2025Trial
- Digital integration of research conduct into clinical care: results of the PROSPECTOR randomised feasibility study.BMJ evidence-based medicine · 2025Trial
- Phase III Trial of Intravenous Mannitol Versus Placebo During Nephron-sparing Surgery: Post Hoc Analysis of 3-yr Outcomes.European urology focus · 2019Trial
- Intraoperative mannitol during robotic-assisted-laparoscopic partial nephrectomy.Journal of robotic surgery · 2019Trial
- Prospective assessment of the impact of intraoperative diuretics in kidney transplant recipient surgery.Canadian journal of surgery. Journal canadien de chirurgieTrial
- The Impact of Intraoperative Dexamethasone and Mannitol on Postoperative Inflammatory Response in Totally Tubeless Percutaneous Nephrolithotomy: A Prospective, Double-Blind, Controlled Clinical Trial.Advances in urology · 2026Article
- Successful completion of large, low-cost randomized cancer trials at an academic cancer center.Clinical trials (London, England) · 2025Article
- Impact of Mannitol Administration on Postoperative Renal Function After Robot-Assisted Partial Nephrectomy.Journal of clinical medicine · 2024Article
- Systemic Changes in Endocannabinoids and Endocannabinoid-like Molecules in Response to Partial Nephrectomy-Induced Ischemia in Humans.International journal of molecular sciences · 2023Article
- Moving away from mannitol infusion for partial nephrectomy: has this altered renal function?Journal of robotic surgery · 2023Article
- Total robotic surgical volume influences outcomes of low-volume robotic-assisted partial nephrectomy over an extended duration.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2021Article
- Robotic-assisted partial nephrectomy (RAPN) and standardization of outcome reporting: a prospective, observational study on reaching the "Trifecta and Pentafecta".Journal of robotic surgery · 2021Observational
- Open partial nephrectomy with kidney split: Effective surgical approach to resect completely endophytic tumors.Urologic oncology · 2021Article
- Open partial nephrectomy: current review.Translational andrology and urology · 2020Review
- Examining Mannitol Use in Kidney Cancer Surgery: A Cautionary Tale of Extrapolated Surgical Data.European urology focus · 2019Article
- General Anesthetic Agents and Renal Function after Nephrectomy.Journal of clinical medicine · 2019Article
- Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic.Journal of nephrology · 2019Review
- National trends of preoperative imaging modalities before partial nephrectomy for renal masses in the U.S. from 2007-2015.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2019Article
- Association of Prevalence of Benign Pathologic Findings After Partial Nephrectomy With Preoperative Imaging Patterns in the United States From 2007 to 2014.JAMA surgery · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMannitol is currently used as a renal protective agent to mitigate the effects of renal ischemia during nephron-sparing surgery (NSS). This routine practice lacks rigorous methodological study.
objectiveTo assess the effect on renal function outcomes after surgery of mannitol infusion prior to renal ischemia during NSS. DESIGN, SETTING,
participantsThis prospective, randomized, placebo-controlled, double-blind trial included 199 patients with a preoperative estimated glomerular filtration rate (eGFR) >45ml/min/1.73m
interventionPatients undergoing NSS were randomized to receive mannitol (12.5g) or placebo intravenously within 30min prior to renal vascular clamping. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary outcome was the difference in eGFR (renal function) between the two groups at 6 mo following surgery assessed with an analysis of covariance model using preoperative eGFR, treatment group, and surgical approach as covariates. RESULTS AND LIMITATIONS: At baseline, the median age of the patients was 58 yr, and the median eGFR was 88ml/min/1.73m
conclusionsIntraoperative 12.5g mannitol infusion during NSS has no demonstrable clinical benefit when compared with standardized fluid hydration in patients with normal preoperative renal function, and its use in this setting is not warranted. PATIENT SUMMARY: In this randomized trial, patients with normal kidney function who received mannitol during surgery to remove part of their kidney had no better kidney function 6 mo after surgery than those who did not receive mannitol. We conclude that this routine practice should be discontinued.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.