Evidence map›Paper›PMID 28822268›Full record

ArticleVirology2017

Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus.

Vrushali Mangale, Brett S Marro, Warren C Plaisted, Craig M Walsh, Thomas E Lane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Promoting remyelination through cell transplantation therapies in a model of viral-induced neurodegenerative disease.Developmental dynamics : an official publication of the American Association of Anatomists · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vrushali MangaleDepartment of Pathology, Division of Microbiology & Immunology University of Utah, Salt Lake City, UT 84112, United States.
Brett S MarroDepartment of Molecular Biology & Biochemistry and Institute for Immunology, University of California, Irvine 92697, United States.
Warren C PlaistedDepartment of Molecular Biology & Biochemistry and Institute for Immunology, University of California, Irvine 92697, United States.
Craig M WalshDepartment of Molecular Biology & Biochemistry and Institute for Immunology, University of California, Irvine 92697, United States.
Thomas E LaneDepartment of Pathology, Division of Microbiology & Immunology University of Utah, Salt Lake City, UT 84112, United States. Electronic address: tom.lane@path.utah.edu.
University of California, Irvine · USUniversity of Utah · US

Funding

Training Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3M
Human neural precursor cell-mediated therapy in a viral model of demyelinationR01NS092042 · NINDS · UNIVERSITY OF UTAH · PI LANE, THOMAS E, LORING, JEANNE F · 2015 to 2019
$2.8M
Viral-induced axonopathy: mechanisms of damage and repairR01NS091939 · NINDS · UNIVERSITY OF UTAH · PI FUJINAMI, ROBERT S, LANE, THOMAS E · 2016 to 2020
$1.7M
Viral-induced demyelination and neural stem cell-mediated remyelinationR01NS074987 · NINDS · UNIVERSITY OF UTAH · PI LANE, THOMAS E · 2011 to 2015
$1.6M
NINDS NIH HHS R01 NS074987NINDS NIH HHS R01 NS091939NINDS NIH HHS R01 NS092042NINDS NIH HHS T32 NS082174
6 · The paper itself

Abstract

The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). Similar to NPCs derived from striatum of day 1 postnatal GFP-transgenic mice (GFP-NPCs), iPSC-derived NPCs (iPSC-NPCs) are able to differentiate into terminal neural cell types and express MHC class I and II in response to IFN-γ treatment. However, in contrast to postnatally-derived NPCs, iPSC-NPCs express low levels of carcinoembryonic antigen-cell adhesion molecule 1a (CEACAM1a), the surface receptor for JHMV, and are less susceptible to infection and virus-induced cytopathic effects. The relevance of this in terms of therapeutic application of NPCs resistant to viral infection is discussed.

Indexed as

Cell DifferentiationAnimalsCarcinoembryonic AntigenGene ExpressionHistocompatibility Antigens Class IHistocompatibility Antigens Class IIInduced Pluripotent Stem CellsInterferon-gammaMiceMice, TransgenicMurine hepatitis virusNeural Stem CellsCarcinoembryonic AntigenCeacam1 protein, mouseHistocompatibility Antigens Class IHistocompatibility Antigens Class IIInterferon-gammaCytopathologyMouse hepatitis virusNeural progenitor cellsViral receptor

Identifiers

PMID28822268
PMCPMC5623645
OpenAlexW2746711459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.