Evidence map›Paper›PMID 28822097›Full record

ArticleInfection2017

A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum.

Esther van de Vosse, Annelies van Wengen, Wendy F van der Meide, Leo G Visser, Jaap T van Dissel

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Human immunity to fungal infections.The Journal of experimental medicine · 2025
    Review
  2. Focal necrotizingRadiology case reports · 2025
    Article
  3. Review
  4. Anticytokine Autoantibodies in Infectious Diseases: A Practical Overview.International journal of molecular sciences · 2023
    Review
  5. Anticytokine Autoantibodies and Fungal Infections.Journal of fungi (Basel, Switzerland) · 2023
    Review
  6. Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity.The Journal of allergy and clinical immunology · 2022
    Review
  7. Review
  8. Review
  9. Minireview: Insights into anti-interferon-γ autoantibodies.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  10. Natural History and Evolution of Anti-Interferon-γ Autoantibody-Associated Immunodeficiency Syndrome in Thailand and the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Esther van de VosseDepartment of Infectious Diseases, Leiden University Medical Center, Room C5-42, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. E.van_de_Vosse@LUMC.nl.ORCID http://orcid.org/0000-0001-5199-3426
Annelies van WengenDepartment of Infectious Diseases, Leiden University Medical Center, Room C5-42, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Wendy F van der MeideU-CyTech Biosciences, Utrecht, The Netherlands.
Leo G VisserDepartment of Infectious Diseases, Leiden University Medical Center, Room C5-42, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Jaap T van DisselDepartment of Infectious Diseases, Leiden University Medical Center, Room C5-42, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

case presentationWe analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum.

conclusionIFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies.

Indexed as

AdultAutoantibodiesFemaleHistoplasmaHistoplasmosisHumansInterferon-gammaLeukocytes, MononuclearLymphadenitisNetherlandsAutoantibodiesInterferon-gammaAutoantibodiesHistoplasmosisHLAIFN-γImmunodeficiency

Identifiers

PMID28822097
PMCPMC5696445
OpenAlexW2748406360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.