ReviewCurrent neurology and neuroscience reports2017
Imaging the Etiology of Apathy, Anxiety, and Depression in Parkinson's Disease: Implication for Treatment.
Review in Current neurology and neuroscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Management of Anxiety in Parkinson's Disease.Movement disorders clinical practice · 2025Pooled it
- Neuroimaging of Anxiety in Parkinson's Disease: A Systematic Review.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- An Open-Label, 8-Week Study of Safety and Efficacy of Pimavanserin Treatment in Adults with Parkinson's Disease and Depression.Journal of Parkinson's disease · 2020Trial
- Differential effects of levodopa on social cognition in people with Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Association between amygdala subregions and non-motor symptoms in Parkinson's disease: a fixel-based analysis.Brain imaging and behavior · 2026Article
- Pallidal beta power is associated with depression in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Network localization of functional and structural correlates of apathy in Parkinson's disease.Frontiers in systems neuroscience · 2026Article
- Sex-specific gray matter underpinnings of anxiety and their mediating mechanisms inFrontiers in aging neuroscience · 2026Article
- Reliability, validity, and diagnostic accuracy of the apathy evaluation scale in chronic stroke survivors.BMC psychiatry · 2025Article
- Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Fatigue and neuropsychiatric symptoms in Parkinson's disease: a narrative review.Frontiers in neurology · 2025Review
- Noradrenergic alterations in Parkinson's disease: a combined 11C-yohimbine PET/neuromelanin MRI study.Brain : a journal of neurology · 2024Article
- Exploring Parkinson's Disease-Associated Depression: Role of Inflammation on the Noradrenergic and Serotonergic Pathways.Brain sciences · 2024Review
- Association between deep gray matter iron deposition and clinical symptoms in Parkinson's disease: a quantitative susceptibility mapping study.Frontiers in neurology · 2024Article
- Behind the Mask: Parkinson's Disease and Depression.Cureus · 2024Review
- Volumetric changes and clinical trajectories in Parkinson's disease: a prospective multicentric study.Journal of neurology · 2023Article
- Exploring depression in Parkinson's disease: an Italian Delphi Consensus on phenomenology, diagnosis, and management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Article
- Common and distinct roles of amygdala subregional functional connectivity in non-motor symptoms of Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Cortical gyrification pattern of depression in Parkinson's disease: a neuroimaging marker for disease severity?Frontiers in aging neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apathy, depression, and anxiety are among the most important non-motor signs of Parkinson's disease (PD). This may be encountered at early stages of illness and represent a major source of burden. Understanding their pathophysiology is a major prerequisite for efficient therapeutic strategies. Anatomical and metabolic imaging studies have enabled a breakthrough by demonstrating that widespread abnormalities within the limbic circuits notably the orbitofrontal and anterior cingulate cortices, amygdala, thalamus, and ventral striatum are involved in the pathophysiology of depression, anxiety, and apathy in PD. Functional imaging has further shown that mesolimbic dopaminergic but also serotonergic lesions play a major role in the mechanisms of these three neuropsychiatric manifestations, which has direct therapeutic implications.
Indexed as
Identifiers
28822071What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.