SynthesisEndocrine2017
Association between serum osteocalcin and body mass index: a systematic review and meta-analysis.
Synthesis in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- The relationship between circulating osteocalcin and muscle mass measurements in humans: A systematic review and meta-analysis.Sports medicine and health science · 2026Review
- Association between insulin resistance biomarkers and metastatic prognosis in treatment-naïve colorectal cancer patients: a pilot study.BMC cancer · 2025Article
- Osteocalcin in human breast milk over the course of lactation.Frontiers in endocrinology · 2025Observational
- Osteokines in Nonalcoholic Fatty Liver Disease.Current obesity reports · 2024Review
- Fetal femur length and risk of diabetes in adolescence: a prospective cohort study.Tropical medicine and health · 2024Article
- Osteocalcin: Beyond Bones.Endocrinology and metabolism (Seoul, Korea) · 2024Review
- Serum Osteocalcin, Sclerostin and Lipocalin-2 Levels in Adolescent Boys with Obesity over a 12-Week Sprint Interval Training.Children (Basel, Switzerland) · 2023Article
- New insight of obesity-associated NAFLD: Dysregulated "crosstalk" between multi-organ and the liver?Genes & diseases · 2023Review
- Age- and sex-specific differences in the association of serum osteocalcin and cardiometabolic risk factors in type 2 diabetes.Diabetology & metabolic syndrome · 2023Article
- Association between osteocalcin, a pivotal marker of bone metabolism, and secretory function of islet beta cells and alpha cells in Chinese patients with type 2 diabetes mellitus: an observational study.Diabetology & metabolic syndrome · 2022Article
- Consistently Low Levels of Osteocalcin From Late Pregnancy to Postpartum Are Related to Postpartum Abnormal Glucose Metabolism in GDM Patients.Frontiers in endocrinology · 2022Article
- Article
- Osteocalcin, Osteopontin and RUNX2 Expression in Patients' Leucocytes with Arteriosclerosis.Diseases (Basel, Switzerland) · 2021Article
- Review
- Association of body mass index and waist circumference with osteocalcin and C-terminal telopeptide in Iranian elderly: results from a cross-sectional study.Journal of bone and mineral metabolism · 2019Article
- Comment on 'Association between serum osteocalcin and body mass index: a systematic review and meta-analysis.'Endocrine · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOsteocalcin is considered as a bone-derived hormone affecting on the body fat distribution and body mass index. Several cross-sectional studies have investigated the association between serum osteocalcin and body mass index. The aim of this study was to summarize the evidence on the relationship between serum osteocalcin and body mass index.
methodsWe conducted a complete search up to November 2016 in PubMed and SCOPUS and reviewed reference list of all relevant articles and reviews. The DerSimonian-Laird method were used to pool effect sizes of eligible studies. The potential sources of heterogeneity were assessed using the standard χ
resultsThere was a significant inverse association in the overall result of this study between serum osteocalcin levels and BMI(r = -0.161; 95% CI: -0.197, -0.124, p < 0.000). In the subgroup analysis to find the sources of significant heterogeneity between-study, we observed that the type of the study population may be the source of between-study heterogeneity and the most correlation was seen in metabolic syndrome studies (r = -0.265; p = 0.000).
conclusionFindings from the available data indicated an overall significant inverse association between serum osteocalcin and body mass index. Further studies based on the type of study population are needed to better clarify these associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.