Evidence map›Paper›PMID 28822038›Full record

ArticleMolecular imaging and biology2018

Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model.

Mohammed N Tantawy, H Charles Manning, Todd E Peterson, Daniel C Colvin, John C Gore, Wenfu Lu, Zhenbang Chen, C Chad Quarles

Open access · greenAbstract read
In one paragraph

Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Preclinical Fluorescence-Guided Imaging Leveraging Surrounding Sentinel Tumor Microenvironment Identifies High-Risk Premalignant Pancreatic Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  3. Review
  4. Article
  5. Evaluation of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  6. Article
  7. TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  8. Translocator Protein (TSPO) as a Potential Biomarker in Human Cancers.International journal of molecular sciences · 2018
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mohammed N TantawyVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, 1161 21st Ave. S., AA 1105 MCN, Nashville, TN, 37232, USA.
H Charles ManningVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, 1161 21st Ave. S., AA 1105 MCN, Nashville, TN, 37232, USA.
Todd E PetersonVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, 1161 21st Ave. S., AA 1105 MCN, Nashville, TN, 37232, USA.
Daniel C ColvinVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, 1161 21st Ave. S., AA 1105 MCN, Nashville, TN, 37232, USA.
John C GoreVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, 1161 21st Ave. S., AA 1105 MCN, Nashville, TN, 37232, USA.
Wenfu LuDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN, 37208, USA.
Zhenbang ChenDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN, 37208, USA.
C Chad QuarlesImaging Research, Barrow Neurological Institute, 350 W Thomas Rd, Phoenix, AZ, 85013, USA. chad.quarles@barrowneuro.org.
Vanderbilt University Medical Center · USMeharry Medical College · USBarrow Neurological Institute · US

Funding

The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Maureen Sanderson · 2017 to 2026
$48.2M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI BALLARD, BILLY RAY · 2011 to 2025
$18.8M
TSPO Ligands for Cancer ImagingR01CA163806 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2012 to 2016
$2.2M
Upgrade of a 7T Small Animal MRI/MRS SystemS10OD019993 · OD · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2015 to 2015
$600k
PET System for Preclinical ResearchS10OD016245 · OD · VANDERBILT UNIVERSITY · PI PETERSON, TODD E · 2013 to 2013
$584k
Small Animal PET ScannerS10RR017858 · NCRR · VANDERBILT UNIVERSITY · PI KESSLER, ROBERT MICHAEL · 2003 to 2003
$500k
Radiofluorination Equipment for PET Imaging ResearchS10OD019963 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2016 to 2016
$291k
Defense Advanced Research Projects Agency W81XWH-12-1-0245NCI NIH HHS R01 CA163806NCI NIH HHS U54 CA163069NCRR NIH HHS S10 RR017858NIH HHS R01 CA163806NIH HHS S10 OD016245NIH HHS S10 OD019993NIH Office of the Director 1S10 OD016245NIH Office of the Director 1S10 RR017858NIMHD NIH HHS U54 MD007586
6 · The paper itself

Abstract

purposeThe identification and targeting of biomarkers specific to prostate cancer (PCa) could improve its detection. Given the high expression of translocator protein (TSPO) in PCa, we investigated the use of [ PROCEDURES: Pten

resultsTumor presence was confirmed by visual inspection of the MR images. The uptake of [

conclusionsThe foregoing preliminary data suggest that TSPO may be a useful biomarker of PCa. Therefore, using TSPO-targeting PET ligands, such as [

Indexed as

Positron-Emission TomographyAnimalsDisease Models, AnimalFluorine RadioisotopesMagnetic Resonance ImagingMaleMiceProstatic NeoplasmsReceptors, GABATomography, X-Ray ComputedBzrp protein, mouseFluorine RadioisotopesReceptors, GABAPETProstate cancerTranslocator protein

Identifiers

PMID28822038
PMCPMC5903879
OpenAlexW2747345073

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.