Evidence map›Paper›PMID 28822028›Full record

Trial reportInternational ophthalmology2018

Effect of diquafosol tetrasodium 3% on the conjunctival surface and clinical findings after cataract surgery in patients with dry eye.

Lian Cui, Ying Li, Hyo Seok Lee, Jee Myung Yang, Won Choi, Kyung Chul Yoon

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03640351 (Clinical Effects of Diquas-S for Patients With Dry Eye After Cataract Surgery), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03640351 nacompletednot on this map

Clinical Effects of Diquas-S for Patients With Dry Eye After Cataract Surgery

TypeinterventionalSponsorYonsei UniversityRan2017 to 2019Enrolled150ConditionsDry Eye, Cataract SurgeryArms1. Use of preservative free diquafosol ophthalmic solution after cataract surgery, 2. Use of preservative containing diquafosol ophthalmic solution after cataract surgery, 3. Use of preservative free sodium hyaluronate ophthalmic solution after cataract surgery
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Topical diquafosol versus hyaluronic acid for the treatment of dry eye disease: a meta-analysis of randomized controlled trials.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Cataract surgery and dry eye disease: A review.European journal of ophthalmology · 2020
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lian CuiDepartment of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Ying LiDepartment of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Hyo Seok LeeDepartment of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Jee Myung YangGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
Won ChoiDepartment of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Kyung Chul YoonDepartment of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea. kcyoon@jnu.ac.kr.ORCID http://orcid.org/0000-0002-2788-1851
Chonnam National University Hospital · KRChonnam National University · KRKorea Advanced Institute of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the effects of diquafosol tetrasodium (DT) 3% on conjunctival impression cytologic findings in addition to clinical symptoms and signs after cataract surgery in patients with preexisting dry eye disease (DED).

methodsNinety-four eyes of 94 patients with DED who underwent uneventful cataract surgery were included. In total, 50 patients were treated with DT 3% (group A), while 44 patients were treated with sodium hyaluronate 0.1% (group B) postoperatively, along with topical antibiotics and steroids. Conjunctival impression cytology was performed at baseline and at 4 and 12 weeks after surgery. Visual acuity, ocular surface disease index (OSDI), tear film breakup time (TBUT), keratoepitheliopathy score, Schirmer's test, and tear clearance rate were measured at baseline and at 1, 4, and 12 weeks, and corneal aberration was analyzed at baseline and at 4 and 12 weeks.

resultsThe grade of conjunctival squamous metaplasia was lower at 12 weeks, and goblet cell density was higher at 4 and 12 weeks in group A than in group B (P < 0.05). Compared with group B, group A showed significantly lower OSDI scores at 4 and 12 weeks, longer TBUT at 1, 4, and 12 weeks, lower keratoepitheliopathy scores at 1 and 12 weeks, and lower total root-mean-square score and spherical aberrations at 4 weeks after surgery (P < 0.05).

conclusionsDT 3% eye drops application after cataract surgery was effective in improving conjunctival epithelial morphology and goblet cell density as well as clinical findings in patients with DED.

Indexed as

Cataract ExtractionCataractCell CountConjunctivaDry Eye SyndromesFemaleFollow-Up StudiesHumansMaleMiddle AgedOphthalmic SolutionsPolyphosphatesPostoperative PeriodProspective StudiesTreatment OutcomeUracil NucleotidesdiquafosolOphthalmic SolutionsPolyphosphatesUracil NucleotidesCataract surgeryDiquafosolDry eyeImpression cytology

Identifiers

PMID28822028
OpenAlexW2748060579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.