ArticleMetabolic brain disease2017
Morus nigra and its major phenolic, syringic acid, have antidepressant-like and neuroprotective effects in mice.
Article in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Antinociceptive and Anti-Inflammatory Effects of Syringic Acid:ACS omega · 2026Article
- Polyphenols: A top-down approach to nutrition and depression.World journal of psychiatry · 2025Review
- Research Progress on Phytochemicals from Mulberry with Neuroprotective Effects: A Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Black Mulberries (Foods (Basel, Switzerland) · 2024Article
- Neuroprotective effects of total phenolics fromFrontiers in pharmacology · 2024Article
- The Emerging Importance of Cirsimaritin in Type 2 Diabetes Treatment.International journal of molecular sciences · 2023Article
- Hydroethanolic Extract of Morus nigra L. Leaves: A Dual PPAR-α/γ Agonist with Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7Plants (Basel, Switzerland) · 2022Article
- The Anxiolytic Activity ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Phenolic Acids as Antidepressant Agents.Nutrients · 2022Review
- Syringic Acid Ameliorates Cardiac, Hepatic, Renal and Neuronal Damage Induced by Chronic Hyperglycaemia in Wistar Rats: A Behavioural, Biochemical and Histological Analysis.Molecules (Basel, Switzerland) · 2022Article
- Phytochemical Composition of Different Botanical Parts ofPlants (Basel, Switzerland) · 2022Review
- Methanolic Extract ofDrug design, development and therapy · 2022Article
- Protective mechanism of Syringic acid in an experimental model of Parkinson's disease.Metabolic brain disease · 2021Article
- Antioxidant-RichPlants (Basel, Switzerland) · 2021Article
- Attitudes Toward Psychological Disorders and Alternative Medicine in Saudi Participants.Frontiers in psychiatry · 2021Article
- Effects of Mulberry on The Central Nervous System: A Literature Review.Current neuropharmacology · 2021Review
- Evaluation and comparison of the antidepressant-like activity ofResearch in pharmaceutical sciences · 2019Article
- Pharmacological Properties ofNutrients · 2019Review
- Greater Protective Potent of s-Methyl Cysteine and Syringic Acid Combination for NGF-differentiated PC12 Cells against Kainic acid-induced Injury.International journal of medical sciences · 2019Article
- Structure⁻Activity Relationship of the Tyrosinase Inhibitors Kuwanon G, Mulberrofuran G, and Albanol B fromMolecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a disorder with a high incidence that has been increasing worldwide although the pathophysiology remains unclear. Moreover, some studies revealed a higher concentration of glutamate and oxidative stress in the patients' brain, which causes cell death by excitotoxicity. Morus nigra L. is known as black mulberry and its leaves are popularly used to treat affections related to menopause, obesity and high cholesterol. M. nigra leaves are a rich fount of phenolics which well-known by the antioxidant property. Herein, we examined the phenolic profile and the antidepressant-like effect of the Morus nigra aqueous extract (MN) and its major phenolic constituent, syringic acid (SA). Furthermore, the involvement of antioxidant and neuroprotective activities were further evaluated. Our results show that acute and subchronic MN or SA administration exerted antidepressant-like property in the behavioral testes in mice. The results suggest that the antidepressant-like effect of MN, at least in part, could be due to the SA influence. Moreover, the observed effect involves the nitro-oxidative system modulation in both the serum and brain of mice. Furthermore, MN or SA was able to contain the glutamate-induced cell death in the hippocampal and cortical slices implicating the neuroprotection activity in the antidepressant-like effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.