Evidence map›Paper›PMID 28822016›Full record

ArticlePurinergic signalling2017

In situ imaging reveals properties of purinergic signalling in trigeminal sensory ganglia in vitro.

Arletta Nowodworska, Arn M J M van den Maagdenberg, Andrea Nistri, Elsa Fabbretti

Open access · bronzeAbstract read
In one paragraph

Article in Purinergic signalling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Functional Coupling between the P2XInternational journal of molecular sciences · 2021
    Article
  9. Article
  10. Current understanding of trigeminal ganglion structure and function in headache.Cephalalgia : an international journal of headache · 2019
    Review
  11. Genetic mouse models of migraine.The journal of headache and pain · 2019
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Arletta NowodworskaNeuroscience Department, International School for Advanced Studies (SISSA), Via Bonomea 265, 34136, Trieste, Italy.
Arn M J M van den MaagdenbergDepartments of Human Genetics & Neurology, University Medical Centre, Einthovenweg 20, 2333 ZC, Leiden, Netherlands.
Andrea NistriNeuroscience Department, International School for Advanced Studies (SISSA), Via Bonomea 265, 34136, Trieste, Italy.
Elsa FabbrettiCenter for Biomedical Sciences and Engineering, University of Nova Gorica, Vipavska 13, 5000, Nova Gorica, Slovenia. e.fabbretti.bf@gmail.com.
Scuola Internazionale Superiore di Studi Avanzati · ITLeiden University Medical Center · NLUniversity of Nova Gorica · SI

Funding

FP7 602633
6 · The paper itself

Abstract

Chronic pain is supported by sterile inflammation that induces sensitisation of sensory neurons to ambient stimuli including extracellular ATP acting on purinergic P2X receptors. The development of in vitro methods for drug screening would be useful to investigate cell crosstalk and plasticity mechanisms occurring during neuronal sensitisation and sterile neuroinflammation. Thus, we studied, at single-cell level, membrane pore dilation based on the uptake of a fluorescent probe following sustained ATP-gated P2X receptor function in neurons and non-neuronal cells of trigeminal ganglion cultures from wild-type (WT) and R192Q Ca

Indexed as

AnimalsCalcitonin Gene-Related PeptideCells, CulturedChronic PainGene Knock-In TechniquesMiceMicroscopy, FluorescenceOptical ImagingReceptors, Purinergic P2X7Signal TransductionTrigeminal GanglionCalcitonin Gene-Related PeptideReceptors, Purinergic P2X7ATPCACNA1ADRGFHM1MigraineP2X3P2X7Pain

Identifiers

PMID28822016
PMCPMC5714839
OpenAlexW2749804873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.