ArticleScientific reports2017
The heat shock response and humoral immune response are mutually antagonistic in honey bees.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Integrated Assessment of Pollen Substitute Diets in Honey Bees Based on Transcriptional Responses, Immune-Derived Predicted Biological Age, and Survival.Animals : an open access journal from MDPI · 2026Article
- Heat shock proteins in farmed aquatic animals: advancing animal health and welfare management through building resilience.Frontiers in immunology · 2026Review
- Remodeling of Cellular Respiration and Insulin Signaling Are Part of a Shared Stress Response in Divergent Bee Species.Insects · 2025Article
- Review
- Climate change-induced stress in the honey beeFrontiers in physiology · 2025Review
- Parent-Specific Transgenerational Immune Priming Enhances Offspring Defense-Unless Heat Stress Negates It All.Ecology and evolution · 2024Article
- Transcriptional control of a metabolic switch regulating cellular methylation reactions is part of a common response to stress in divergent bee species.The Journal of experimental biology · 2024Article
- A simulated natural heatwave perturbs bumblebee immunity and resistance to infection.The Journal of animal ecology · 2024Article
- Indirect exposure to insect growth disruptors affects honey bee (Apis mellifera) reproductive behaviors and ovarian protein expression.PloS one · 2023Article
- Acute oral toxicity, apoptosis, and immune response in nurse bees (Frontiers in physiology · 2023Article
- Effects of Thiamethoxam-Dressed Oilseed Rape Seeds andInsects · 2022Article
- Drone honey bees are disproportionately sensitive to abiotic stressors despite expressing high levels of stress response proteins.Communications biology · 2022Article
- Review
- Phylogenetic annotation ofmicroPublication biology · 2022Article
- Honey bee sHSP are responsive to diverse proteostatic stresses and potentially promising biomarkers of honey bee stress.Scientific reports · 2021Article
- Proteasome Inhibition Is an Effective Treatment Strategy for Microsporidia Infection in Honey Bees.Biomolecules · 2021Article
- Changes in haemolymph parameters and insect ability to respond to immune challenge during overwintering.Ecology and evolution · 2021Article
- Thermal niches of specialized gut symbionts: the case of social bees.Proceedings. Biological sciences · 2021Article
- Chemical Stimulants and Stressors Impact the Outcome of Virus Infection and Immune Gene Expression in Honey Bees (Frontiers in immunology · 2021Article
- Reproductive potential does not cause loss of heat shock response performance in honey bees.Scientific reports · 2020Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The honey bee is of paramount importance to humans in both agricultural and ecological settings. Honey bee colonies have suffered from increased attrition in recent years, stemming from complex interacting stresses. Defining common cellular stress responses elicited by these stressors represents a key step in understanding potential synergies. The proteostasis network is a highly conserved network of cellular stress responses involved in maintaining the homeostasis of protein production and function. Here, we have characterized the Heat Shock Response (HSR), one branch of this network, and found that its core components are conserved. In addition, exposing bees to elevated temperatures normally encountered by honey bees during typical activities results in robust HSR induction with increased expression of specific heat shock proteins that was variable across tissues. Surprisingly, we found that heat shock represses multiple immune genes in the abdomen and additionally showed that wounding the cuticle of the abdomen results in decreased expression of multiple HSR genes in proximal and distal tissues. This mutually antagonistic relationship between the HSR and immune activation is unique among invertebrates studied to date and may promote understanding of potential synergistic effects of disparate stresses in this critical pollinator and social insects more broadly.
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