ArticleScientific reports2017
Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Investigating spontaneous retinal venous pulsation using Doppler optical coherence tomography.Scientific reports · 2019Trial
- In-vivo characterization of scleral rigidity in myopic eyes using fundus-pulsation optical coherence elastography.Biomedical optics express · 2024Article
- Pulsatile tissue deformation dynamics of the murine retina and choroid mapped by 4D optical coherence tomography.Biomedical optics express · 2022Article
- Retrobulbar blood flow in rat eyes during acute elevation of intraocular pressure.Experimental eye research · 2021Article
- A proof of concept study to evaluate the treatment response of aflibercept in wARMD using OCT-A (Canada study).International ophthalmology · 2021Article
- Macular vascular changes in pregnant women with gestational diabetes mellitus by optical coherence tomography angiography.BMC ophthalmology · 2021Article
- Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes.Investigative ophthalmology & visual science · 2020Article
- Relationship Between the Parameters of Corneal and Fundus Pulse Signals Acquired With a Combined Ultrasound and Laser Interferometry Technique.Translational vision science & technology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A multi-functional optical coherence tomography (OCT) approach is presented to determine ocular fundus pulsations as an axial displacement between the retina and the chorioscleral complex in the albino rat eye. By combining optical coherence elastography and OCT angiography (OCTA), we measure subtle deformations in the nanometer range within the eye and simultaneously map retinal and choroidal perfusion. The conventional OCT reflectivity contrast serves as a backbone to segment the retina and to define several slabs which are subsequently used for quantitative ocular pulsation measurements as well as for a qualitative exploration of the multi-functional OCT image data. The proposed concept is applied in healthy albino rats as well as in rats under acute elevation of the intraocular pressure (IOP). The evaluation of this experiment revealed an increased pulsatility and deformation between the retinal and chorioscleral complex while increasing the IOP level from 15 mmHg to 65 mmHg. At IOP levels exceeding 65 mmHg, the pulsatility decreased significantly and retinal as well as choroidal perfusion vanished in OCTA. Furthermore, the evaluation of the multi-parametric experiment revealed a spatial correlation between fundus pulsatility and choroidal blood flow. This indicates that the assessed pulsatility may be a valuable parameter describing the choroidal perfusion.
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