Evidence map›Paper›PMID 28821822›Full record

ArticleScientific reports2017

Bladder Cancer Treatment Response Assessment in CT using Radiomics with Deep-Learning.

Kenny H Cha, Lubomir Hadjiiski, Heang-Ping Chan, Alon Z Weizer, Ajjai Alva, Richard H Cohan, Elaine M Caoili, Chintana Paramagul, Ravi K Samala

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed.

  1. Japanese journal of radiology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. A CT-based interpretable deep learning signature for predicting PD-L1 expression in bladder cancer: a two-center study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Artificial intelligence for predicting response to neoadjuvant chemotherapy for bladder cancer A comprehensive systematic review and meta-analysis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024
    Review
  15. Automated Lugano Metabolic Response Assessment inJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  16. Review
  17. [Deep transfer learning radiomics model based on temporal bone CT for assisting in the diagnosis of inner ear malformations].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  18. Article
  19. Review
  20. Bladder Cancer and Artificial Intelligence: Emerging Applications.The Urologic clinics of North America · 2024
    Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kenny H ChaDepartment of Radiology, The University of Michigan, Ann Arbor, Michigan, 48109, United States. heekon@med.umich.edu.
Lubomir HadjiiskiDepartment of Radiology, The University of Michigan, Ann Arbor, Michigan, 48109, United States.
Heang-Ping ChanDepartment of Radiology, The University of Michigan, Ann Arbor, Michigan, 48109, United States.
Alon Z WeizerDepartment of Urology, Comprehensive Cancer Center, The University of Michigan, Ann Arbor, Michigan, 48109, United States.
Ajjai AlvaDepartment of Internal Medicine, Hematology-Oncology, The University of Michigan, Ann Arbor, Michigan, 48109, United States.
Richard H CohanDepartment of Radiology, The University of Michigan, Ann Arbor, Michigan, 48109, United States.
Elaine M CaoiliDepartment of Radiology, The University of Michigan, Ann Arbor, Michigan, 48109, United States.
Chintana ParamagulDepartment of Radiology, The University of Michigan, Ann Arbor, Michigan, 48109, United States.
Ravi K SamalaDepartment of Radiology, The University of Michigan, Ann Arbor, Michigan, 48109, United States.ORCID 0000-0002-6661-4801

Funding

Biomarkers for Staging and Treatment Response Monitoring of Bladder CancerU01CA179106 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HADJIYSKI, LUBOMIR M · 2014 to 2017
$2.2M
NCI NIH HHS U01 CA179106
6 · The paper itself

Abstract

Cross-sectional X-ray imaging has become the standard for staging most solid organ malignancies. However, for some malignancies such as urinary bladder cancer, the ability to accurately assess local extent of the disease and understand response to systemic chemotherapy is limited with current imaging approaches. In this study, we explored the feasibility that radiomics-based predictive models using pre- and post-treatment computed tomography (CT) images might be able to distinguish between bladder cancers with and without complete chemotherapy responses. We assessed three unique radiomics-based predictive models, each of which employed different fundamental design principles ranging from a pattern recognition method via deep-learning convolution neural network (DL-CNN), to a more deterministic radiomics feature-based approach and then a bridging method between the two, utilizing a system which extracts radiomics features from the image patterns. Our study indicates that the computerized assessment using radiomics information from the pre- and post-treatment CT of bladder cancer patients has the potential to assist in assessment of treatment response.

Indexed as

Deep LearningTomography, X-Ray ComputedAdultAgedAged, 80 and overFemaleHumansImage Processing, Computer-AssistedMaleMedical InformaticsMiddle AgedROC CurveTreatment OutcomeUrinary Bladder Neoplasms

Identifiers

PMID28821822
PMCPMC5562694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.