Evidence map›Paper›PMID 28821786›Full record

ArticleScientific reports2017

Co-Registration of ex vivo Surgical Histopathology and in vivo T2 weighted MRI of the Prostate via multi-scale spectral embedding representation.

Lin Li, Shivani Pahwa, Gregory Penzias, Mirabela Rusu, Jay Gollamudi, Satish Viswanath, Anant Madabhushi

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Improved ground truth annotation by multimodal image registration from 3D ultrasound to histopathology for resected tongue carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Harnessing non-destructive 3D pathology.Nature biomedical engineering · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lin LiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, 44106, United States of America. lxl477@case.edu.ORCID 0000-0003-4196-5813
Shivani PahwaDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, 44106, United States of America.
Gregory PenziasDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, 44106, United States of America.
Mirabela RusuGE Global Research, Niskayuna, New York, 12309, United States of America.ORCID 0000-0002-0372-0367
Jay GollamudiUniversity Hospitals, Cleveland, Ohio, 44106, United States of America.
Satish ViswanathDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, 44106, United States of America.
Anant MadabhushiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, 44106, United States of America. axm788@case.edu.

Funding

Pathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9M
Comprehensive quantitative ultrafast 3D liver MRIR01DK098503 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI GULANI, VIKAS, SEIBERLICH, NICOLE · 2013 to 2017
$2.6M
Histologic image-based aggressiveness prediction in p16+ oropharyngeal carcinomaR21CA179327 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MADABHUSHI, ANANT · 2014 to 2015
$389k
Computerized morphologic-molecular predictor of progression in DCISR21CA195152 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI BADVE, SUNIL S., MADABHUSHI, ANANT · 2015 to 2016
$388k
NCI NIH HHS R21 CA179327NCI NIH HHS R21 CA195152NCI NIH HHS U24 CA199374NIDDK NIH HHS R01 DK098503
6 · The paper itself

Abstract

Multi-modal image co-registration via optimizing mutual information (MI) is based on the assumption that intensity distributions of multi-modal images follow a consistent relationship. However, images with a substantial difference in appearance violate this assumption, thus MI directly based on image intensity alone may be inadequate to drive similarity based co-registration. To address this issue, we introduce a novel approach for multi-modal co-registration called Multi-scale Spectral Embedding Registration (MSERg). MSERg involves the construction of multi-scale spectral embedding (SE) representations from multimodal images via texture feature extraction, scale selection, independent component analysis (ICA) and SE to create orthogonal representations that decrease the dissimilarity between the fixed and moving images to facilitate better co-registration. To validate the MSERg method, we aligned 45 pairs of in vivo prostate MRI and corresponding ex vivo histopathology images. The dataset was split into a learning set and a testing set. In the learning set, length scales of 5 × 5, 7 × 7 and 17 × 17 were selected. In the independent testing set, we compared MSERg with intensity-based registration, multi-attribute combined mutual information (MACMI) registration and scale-invariant feature transform (SIFT) flow registration. Our results suggest that multi-scale SE representations generated by MSERg are found to be more appropriate for radiology-pathology co-registration.

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingAlgorithmsHumansMaleProstate

Identifiers

PMID28821786
PMCPMC5562695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.