ArticleScientific reports2017
Thermal acclimation mitigates cold-induced paracellular leak from the Drosophila gut.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 68 citations in OpenAlex.
- Transcriptomic responses of red palm weevil (Coleoptera: Curculionidae) larvae to low-temperature exposure.Journal of insect science (Online) · 2026Article
- Gut yeasts accelerate chill coma recovery in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- Tryptophan catabolism reprograms immunity to prevent hemolymph bacterial dysbiosis and support molting in Spätzle-deficient Helicoverpa armigera larvae.BMC biology · 2026Article
- Clodronate Liposomes Untangle the Role of Hemocytes in <italic>Apis mellifera</italic> Response to Temperature Variation and Microbial Infection.Journal of innate immunity · 2026Article
- Clodronate liposomes untangle the role of hemocytes inbioRxiv : the preprint server for biology · 2025Article
- Single-nucleus multiome ATAC and RNA sequencing reveals the molecular basis of thermal acclimation inbioRxiv : the preprint server for biology · 2025Article
- Translocation of gut bacteria promotes tumor-associated mortality by inducing immune-activated renal damage.The EMBO journal · 2025Article
- Navigating the Cold: Integrative Transcriptome Sequencing Approach Reveals Ionoregulatory and Whole-Body Responses to Cold Acclimation in Drosophila ananassae.Genome biology and evolution · 2025Article
- Molecular signatures of diapause in the Asian longhorned beetle: Gene expression.Current research in insect science · 2023Article
- A lack of repeatability creates the illusion of a trade-off between basal and plastic cold tolerance.Proceedings. Biological sciences · 2021Article
- Hyperkalaemia, not apoptosis, accurately predicts insect chilling injury.Proceedings. Biological sciences · 2020Article
- Enteric pH responsive cargo release from PDA and PEG coated mesoporous silica nanoparticles: a comparative study inRSC advances · 2020Article
- The septate junction protein Mesh is required for epithelial morphogenesis, ion transport, and paracellular permeability in theAmerican journal of physiology. Cell physiology · 2020Article
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- Transcriptional analysis of insect extreme freeze tolerance.Proceedings. Biological sciences · 2019Article
- Effect of dietary additives on intestinal permeability in bothDisease models & mechanisms · 2018Article
- Microbiota disruption leads to reduced cold tolerance in Drosophila flies.Die Naturwissenschaften · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chill susceptible insects suffer tissue damage and die at low temperatures. The mechanisms that cause chilling injury are not well understood but a growing body of evidence suggests that a cold-induced loss of ion and water homeostasis leads to hemolymph hyperkalemia that depolarizes cells, leading to cell death. The apparent root of this cascade is the net leak of osmolytes down their concentration gradients in the cold. Many insects, however, are capable of adjusting their thermal physiology, and cold-acclimated Drosophila can maintain homeostasis and avoid injury better than warm-acclimated flies. Here, we test whether chilling causes a loss of epithelial barrier function in female adult Drosophila, and provide the first evidence of cold-induced epithelial barrier failure in an invertebrate. Flies had increased rates of paracellular leak through the gut epithelia at 0 °C, but cold acclimation reduced paracellular permeability and improved cold tolerance. Improved barrier function was associated with changes in the abundance of select septate junction proteins and the appearance of a tortuous ultrastructure in subapical intercellular regions of contact between adjacent midgut epithelial cells. Thus, cold causes paracellular leak in a chill susceptible insect and cold acclimation can mitigate this effect through changes in the composition and structure of transepithelial barriers.
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