ArticleScientific reports2017
The integration of Gβ and MAPK signaling cascade in zygote development.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- The sperm cell-surface protein GEX3 coordinates with GEX2 and DMP8/9 to mediate sperm-egg adhesion and fusion in Arabidopsis.Plant communications · 2026Article
- Molecular understanding of plant pollination, fertilization, seed development and protoplast regeneration.Science China. Life sciences · 2026Review
- Plant G proteins: Versatile signaling hubs for synergistic improvement of agronomic traits.Journal of integrative plant biology · 2026Review
- Article
- GR5 acts in the G protein pathway to regulate grain size in rice.Plant communications · 2024Article
- Specificity models in MAPK cascade signaling.FEBS open bio · 2023Review
- Dichotomy of the BSL phosphatase signaling spatially regulates MAPK components in stomatal fate determination.Nature communications · 2022Article
- Regulatory Mechanisms of Mitogen-Activated Protein Kinase Cascades in Plants: More than Sequential Phosphorylation.International journal of molecular sciences · 2022Review
- MAP kinase cascades in plant development and immune signaling.EMBO reports · 2022Review
- Receptor-like protein kinases in plant reproduction: Current understanding and future perspectives.Plant communications · 2022Review
- Lectin receptor-like kinase LecRK-VIII.2 is a missing link in MAPK signaling-mediated yield control.Plant physiology · 2021Article
- Receptor-Like Protein Kinases Function Upstream of MAPKs in Regulating Plant Development.International journal of molecular sciences · 2020Review
- The MAPK substrate MASS proteins regulate stomatal development in Arabidopsis.PLoS genetics · 2020Article
- Plasmogamic Paternal Contributions to Early Zygotic Development in Flowering Plants.Frontiers in plant science · 2020Review
- The Solanum chacoense Fertilization-Related Kinase 3 (ScFRK3) is involved in male and female gametophyte development.BMC plant biology · 2019Article
- Constitutive signaling activity of a receptor-associated protein links fertilization with embryonic patterning inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Role of Gβ Protein in Controlling Cell Expansion via Potential Interaction with Lipid Metabolic Pathways.Plant physiology · 2019Article
- Ectopic Expression of Mulberry G-Proteins Alters Drought and Salt Stress Tolerance in Tobacco.International journal of molecular sciences · 2018Article
- Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis.The Plant cell · 2018Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells respond to many signals with a limited number of signaling components. Heterotrimeric G proteins and MAPK cascades are universally used by eukaryotic cells to transduce signals in various developmental processes or stress responses by activating different effectors. MAPK cascade is integrated with G proteins by scaffold protein during plant immunity. However, the molecular relationship between G proteins and MAPK modules in plant development is still unclear. In this study, we demonstrate that Arabidopsis Gβ protein AGB1 interacts with MPK3 and 6, MKK4 and 5, as well as the regulatory domains of YODA (YDA), the upstream MEKK of MKK4/5. Remarkably, YDA interacts with the plasma membrane associated SHORT SUSPENSOR (SSP) through its N- and C-terminal region in vitro and in vivo. Additionally, genetic analysis shows that AGB1 functions together with MPK3/6 signaling cascade during the asymmetric division of the zygote. These data indicate that Gβ may function likely as a scaffold, through direct physical interaction with the components of the MPK signaling module in plant development. Our results provide new insights into the molecular functions of G protein and will advance the understanding of the complex mechanism of kinase signaling cascades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.