ArticleScientific reports2017
Neural circuitry governing anxious individuals' mis-allocation of working memory to threat.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- The impact of affective information on working memory: A pair of meta-analytic reviews of behavioral and neuroimaging evidence.Psychological bulletin · 2019Pooled it
- Attachment Style, Task Difficulty, and Feedback Type: Effects on Cognitive Load.Behavioral sciences (Basel, Switzerland) · 2025Article
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- Heart rate response to cognitive load as a marker of depression and increased anxiety.Frontiers in psychiatry · 2024Article
- Alterations in working memory maintenance of fearful face distractors in depressed participants: An ERP study.Journal of vision · 2023Article
- Resting-state connectivity subtype of comorbid PTSD and alcohol use disorder moderates improvement from integrated prolonged exposure therapy in Veterans.Psychological medicine · 2023Article
- Connectivity patterns evoked by fearful faces demonstrate reduced flexibility across a shared dimension of adolescent anxiety and depression.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Distinct Effects of Anxiety and Depression on Updating Emotional Information in Working Memory.International journal of environmental research and public health · 2022Article
- Intra-mPFC injection of sodium butyrate promotes BDNF expression and ameliorates extinction recall impairment in an experimental paradigm of post-traumatic stress disorder.Iranian journal of basic medical sciences · 2022Article
- Neutral and threatening distracter word stimuli are unnecessarily stored in working memory but do not differ in their degree of working memory storage.Biological psychology · 2021Article
- Article
- Negative and Positive Bias for Emotional Faces: Evidence from the Attention and Working Memory Paradigms.Neural plasticity · 2021Review
- Patients with anxiety disorders rely on bilateral dlPFC activation during verbal working memory.Social cognitive and affective neuroscience · 2020Article
- Fear not! Anxiety biases attentional enhancement of threat without impairing working memory filtering.Cognitive, affective & behavioral neuroscience · 2020Article
- State anxiety reduces working memory capacity but does not impact filtering cost for neutral distracters.Psychophysiology · 2020Article
- Individual differences in fear acquisition: multivariate analyses of different emotional negativity scales, physiological responding, subjective measures, and neural activation.Scientific reports · 2020Article
- Social context and the real-world consequences of social anxiety.Psychological medicine · 2020Article
- Dopamine: from prediction error to psychotherapy.Translational psychiatry · 2020Review
- Exercise alters brain activation in Gulf War Illness and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Brain communications · 2020Article
- Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework.Progress in brain research · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Dispositional anxiety is a trait-like phenotype that confers increased risk for a range of debilitating neuropsychiatric disorders. Like many patients with anxiety disorders, individuals with elevated levels of dispositional anxiety are prone to intrusive and distressing thoughts in the absence of immediate threat. Recent electrophysiological research suggests that these symptoms are rooted in the mis-allocation of working memory (WM) resources to threat-related information. Here, functional MRI was used to identify the network of brain regions that support WM for faces and to quantify the allocation of neural resources to threat-related distracters in 81 young adults. Results revealed widespread evidence of mis-allocation. This was evident in both face-selective regions of the fusiform cortex and domain-general regions of the prefrontal and parietal cortices. This bias was exaggerated among individuals with a more anxious disposition. Mediation analyses provided compelling evidence that anxious individuals' tendency to mis-allocate WM resources to threat-related distracters is statistically explained by heightened amygdala reactivity. Collectively, these results provide a neurocognitive framework for understanding the pathways linking anxious phenotypes to the development of internalizing psychopathology and set the stage for developing improved intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.