ArticleScientific reports2017
Metabolomics and genomics combine to unravel the pathway for the presence of fragrance in rice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Metabolite Quantitative Trait Loci Mapping for Fragrance and Fatty Acid Composition in Rice (Oryza Sativa L.).Rice (New York, N.Y.) · 2025Article
- Exogenous application of abscisic acid enhanced 2-acetyl-1-pyrroline biosynthesis, accumulation, and antioxidant activities in aromatic rice.BMC plant biology · 2025Article
- The Aroma of Non-Fermented and Fermented Dry-Cured Meat Products: Savory and Toasted Odors.Foods (Basel, Switzerland) · 2025Review
- Metabonomic and transcriptomic profiling reveals amino acid metabolism affects the quality of premium japonica rice varieties in Northeast China.Food chemistry. Molecular sciences · 2024Article
- Metabolome and Transcriptome Unveil the Correlated Metabolites and Transcripts with 2-acetyl-1-pyrroline in Fragrant Rice.International journal of molecular sciences · 2024Article
- Metabolite Profiling of Wheat Response to Cultivar Improvement and Nitrogen Fertilizer.Metabolites · 2023Article
- Determination of 2-Acetyl-1-pyrroline via a Color-Change Reaction Using Chromium Hexacarbonyl.Molecules (Basel, Switzerland) · 2022Article
- Production of aromatic three-line hybrid rice using novel alleles of BADH2.Plant biotechnology journal · 2022Article
- Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities.Natural product reports · 2021Review
- Consumer Acceptance of Brown and White Rice Varieties.Foods (Basel, Switzerland) · 2021Article
- Toward Integrated Multi-Omics Intervention: Rice Trait Improvement and Stress Management.Frontiers in plant science · 2021Review
- Promoting Human Nutrition and Health through Plant Metabolomics: Current Status and Challenges.Biology · 2020Review
- Article
- Metabolite database for root, tuber, and banana crops to facilitate modern breeding in understudied crops.The Plant journal : for cell and molecular biology · 2020Article
- Evaluation of Whole-Genome Sequence, Genetic Diversity, and Agronomic Traits of Basmati Rice (Frontiers in genetics · 2020Article
- Nitrogen application and different water regimes at booting stage improved yield and 2-acetyl-1-pyrroline (2AP) formation in fragrant rice.Rice (New York, N.Y.) · 2019Article
- Urinary volatile metabolites of amygdala-kindled mice reveal novel biomarkers associated with temporal lobe epilepsy.Scientific reports · 2019Article
- The Future of Digital Sequence Information for Plant Genetic Resources for Food and Agriculture.Frontiers in plant science · 2019Article
- Comparative Rice Bran Metabolomics across Diverse Cultivars and Functional Rice Gene⁻Bran Metabolite Relationships.Metabolites · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since it was first characterised in 1983, 2-acetyl-1-pyrroline (2AP) has been considered to be the most important aroma compound in rice. In this study, we show four other amine heterocycles: 6-methyl, 5-oxo-2,3,4,5-tetrahydropyridine (6M5OTP), 2-acetylpyrrole, pyrrole and 1-pyrroline, that correlate strongly with the production of 2AP, and are present in consistent proportions in a set of elite aromatic rice varieties from South East Asia and Australia as well as in a collection of recombinant inbred lines (RILs) derived from indica Jasmine-type varieties, Australian long grain varieties (temperate japonica) and Basmati-type rice (Grp V). These compounds were detected through untargeted metabolite profiling by two-dimensional gas chromatography-time-of-flight mass spectrometry (GC × GC-TOF-MS), and their identity were confirmed by comparison with authentic standards analysed using gas chromatography mass spectrometry (GC-MS) and High Resolution GC × GC-TOF-MS (GC × GC HRT-4D). Genome-wide association analysis indicates that all compounds co-localised with a single quantitative trait locus (QTL) that harbours the FGR gene responsible for the production of GABA. Together, these data provide new insights into the production of 2AP, and evidence for understanding the pathway leading to the accumulation of aroma in fragrant rice.
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