Evidence map›Paper›PMID 28821731›Full record

ArticleScientific reports2017

Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation.

M Glymenaki, A Barnes, S O'Hagan, G Warhurst, A J McBain, I D Wilson, D B Kell, K J Else, S M Cruickshank

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Microorganisms · 2020
    Article
  7. Gastrointestinal Microbiome - What We Need to Know in Clinical Practice.GE Portuguese journal of gastroenterology · 2020
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

M GlymenakiFaculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0003-4552-2438
A BarnesShimadzu Corporation, Manchester, UK.
S O'HaganSchool of Chemistry, University of Manchester, Manchester, UK; Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.
G WarhurstInfection, Injury and Inflammation Research Group, Division of Medicine and Neurosciences, University of Manchester and Salford Royal Hospitals NHS Trust, Salford, UK.
A J McBainFaculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0002-5255-5425
I D WilsonSection of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College, London, UK.ORCID 0000-0002-8558-7394
D B KellSchool of Chemistry, University of Manchester, Manchester, UK; Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.ORCID 0000-0001-5838-7963
K J ElseFaculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
S M CruickshankFaculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. sheena.cruickshank@manchester.ac.uk.ORCID 0000-0002-3047-5475
University of Manchester · GBImperial College London · GBManchester Academic Health Science Centre · GBSalford Royal Hospital · GBShimadzu (United Kingdom) · GB

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is associated with altered microbiota composition and metabolism, but it is unclear whether these changes precede inflammation or are the result of it since current studies have mainly focused on changes after the onset of disease. We previously showed differences in mucus gut microbiota composition preceded colitis-induced inflammation and stool microbial differences only became apparent at colitis onset. In the present study, we aimed to investigate whether microbial dysbiosis was associated with differences in both predicted microbial gene content and endogenous metabolite profiles. We examined the functional potential of mucus and stool microbial communities in the mdr1a

Indexed as

Gastrointestinal MicrobiomeMetabolomeMetabolomicsPhenotypeAnimalsChromatography, High Pressure LiquidColitisDisease Models, AnimalDisease SusceptibilityGenotypeInflammatory Bowel DiseasesMaleMass SpectrometryMetagenomeMetagenomicsMiceRNA, Ribosomal, 16S

Identifiers

PMID28821731
PMCPMC5562868
OpenAlexW2749003295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.