Evidence map›Paper›PMID 28821712›Full record

ArticleScientific reports2017

Emergence of recombinant Mayaro virus strains from the Amazon basin.

Carla Mavian, Brittany D Rife, James Jarad Dollar, Eleonora Cella, Massimo Ciccozzi, Mattia C F Prosperi, John Lednicky, J Glenn Morris, Ilaria Capua, Marco Salemi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  10. Safety concern of recombination between self-amplifying mRNA vaccines and viruses is mitigated in vivo.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
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  18. Analysis of Zika Virus Sequence Data Associated with a School Cohort in Haiti.The American journal of tropical medicine and hygiene · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Carla MavianEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Brittany D RifeEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
James Jarad DollarEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Eleonora CellaDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0002-7870-9744
Massimo CiccozziDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
Mattia C F ProsperiDepartment of Epidemiology, University of Florida, Gainesville, FL, USA.
John LednickyEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
J Glenn MorrisEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Ilaria CapuaOne Health Center of Excellence, University of Florida, Gainesville, FL, USA. icapua@ufl.edu.
Marco SalemiEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA. salemi@pathology.ufl.edu.
University of Florida · USIstituto Superiore di Sanità · ITUniversità Campus Bio-Medico · ITUniversity of Florida Health · US

Funding

Recurrence of Cholera in Haiti: Exploration of Contributing Factors and Intervention StrategiesR01AI126357 · NIAID · UNIVERSITY OF FLORIDA · PI John Glenn Morris · 2016 to 2026
$7.3M
NIAID NIH HHS R01 AI126357
6 · The paper itself

Abstract

Mayaro virus (MAYV), causative agent of Mayaro Fever, is an arbovirus transmitted by Haemagogus mosquitoes. Despite recent attention due to the identification of several cases in South and Central America and the Caribbean, limited information on MAYV evolution and epidemiology exists and represents a barrier to prevention of further spread. We present a thorough spatiotemporal evolutionary study of MAYV full-genome sequences collected over the last sixty years within South America and Haiti, revealing recent recombination events and adaptation to a broad host and vector range, including Aedes mosquito species. We employed a Bayesian phylogeography approach to characterize the emergence of recombinants in Brazil and Haiti and report evidence in favor of the putative role of human mobility in facilitating recombination among MAYV strains from geographically distinct regions. Spatiotemporal characteristics of recombination events and the emergence of this previously neglected virus in Haiti, a known hub for pathogen spread to the Americas, warrants close monitoring of MAYV infection in the immediate future.

Indexed as

AedesAlphavirusAnimalsBayes TheoremBrazilCodonGenetic CodeGenome, ViralGenotypeHumansLikelihood FunctionsPhylogenyPhylogeographyRecombination, GeneticSelection, GeneticTime FactorsCodon

Identifiers

PMID28821712
PMCPMC5562835
OpenAlexW2746457582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.