ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Disruption of M1 Activity during Performance Plateau Impairs Consolidation of Motor Memories.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Acute pain impairs retention of locomotor learning.Journal of neurophysiology · 2024Trial
- The decay and consolidation of effector-independent motor memories.Scientific reports · 2022Trial
- Behaviourally driven closed-loop beta-tACS enhances beta activity and motor behaviour.Nature communications · 2026Article
- Concurrent Bilateral M1 and Anodal Cerebellar tDCS Effects on Learning of a Bimanual Video Game Task.Brain and behavior · 2025Article
- Transcutaneous spinal random noise stimulation enhances motor memory consolidation and corticospinal transmission in humans.The Journal of physiology · 2025Article
- The Consolidation of Newly Learned Movements Depends upon the Somatosensory Cortex in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The human somatosensory cortex contributes to the encoding of newly learned movements.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- No effect of whole-hand water flow stimulation on skill acquisition and retention during sensorimotor adaptation.Frontiers in human neuroscience · 2024Article
- Article
- The effects of post-learning alcohol ingestion on human motor memory consolidation.The European journal of neuroscience · 2022Article
- Adaptive control of movement deceleration during saccades.PLoS computational biology · 2021Article
- Early stages of sensorimotor map acquisition: neurochemical signature in primary motor cortex and its relation to functional connectivity.Journal of neurophysiology · 2020Article
- Dexterous Object Manipulation Requires Context-Dependent Sensorimotor Cortical Interactions in Humans.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Article
- Luring the Motor System: Impact of Performance-Contingent Incentives on Pre-Movement Beta-Band Activity and Motor Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Direction of TDCS current flow in human sensorimotor cortex influences behavioural learning.Brain stimulationArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon exposure to a new sensorimotor relationship, motor behaviors iteratively change early in adaptation but eventually stabilize as adaptation proceeds. Behavioral work suggests that motor memory consolidation is initiated upon the attainment of asymptotic levels of performance. Separate lines of evidence point to a critical role of the primary motor cortex (M1) in consolidation. However, a causal relationship between M1 activity during asymptote and consolidation has yet to be demonstrated. The present study investigated this issue in male and female participants using single-pulse transcranial magnetic stimulation (TMS) to interfere with postmovement activity in M1 in two behavioral phases of a ramp-and-hold visuomotor adaptation paradigm. TMS was either provided after each trial of the ramp phase of adaptation when a gradual increase in the visuomotor rotation caused movements to be changing, or after each trial of the hold phase of adaptation when the rotation was held constant and movements tended to stabilize. Consolidation was assessed by measuring performance on the same task 24 h later. Results revealed that TMS did not influence adaptation to the new visuomotor relationship in either condition. Critically, however, TMS disruption of M1 activity selectively impaired consolidation of motor memories when it was provided during the hold phase of adaptation. This effect did not take place when TMS was delivered over adjacent dorsal premotor cortex or when motor behaviors in late adaptation were prevented from plateauing. Together, these data suggest that the impaired consolidation stemmed from interference with mechanisms of repetition-dependent plasticity in M1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.