Evidence map›Paper›PMID 28821666›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by

Trung N Le, Qing-Ping Zhou, Inma Cobos, Shunzhen Zhang, Jamie Zagozewski, Sara Japoni, Jerry Vriend, Tracie Parkinson, Guoyan Du, John L Rubenstein and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. A compact GAD67 promoter enables inhibitory neuron-targeted AAV gene therapy for seizure suppression.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
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  19. DLX genes and proteins in mammalian forebrain development.Development (Cambridge, England) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Trung N LeDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.
Qing-Ping ZhouDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.
Inma CobosNina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158.
Shunzhen ZhangDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.
Jamie ZagozewskiDepartment of Medical Genetics, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.ORCID 0000-0002-6396-075X
Sara JaponiDepartment of Medical Genetics, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Jerry VriendDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.ORCID 0000-0001-6435-755X
Tracie ParkinsonDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.
Guoyan DuDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.
John L RubensteinNina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158.ORCID 0000-0002-4414-7667
David D EisenstatDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada, eisensta@ualberta.ca.ORCID 0000-0002-5976-0798
University of Manitoba · CAUniversity of Alberta · CAUniversity of California, San Francisco · USSunnybrook Health Science Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GABA is the key inhibitory neurotransmitter in the cortex but regulation of its synthesis during forebrain development is poorly understood. In the telencephalon, members of the distal-less (

Indexed as

AnimalsBasal ForebrainCell DifferentiationCell MovementCells, CulturedFemaleGABAergic Neuronsgamma-Aminobutyric AcidGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicGlutamate DecarboxylaseHomeodomain ProteinsInterneuronsMaleMiceMice, KnockoutDistal-less homeobox proteinsgamma-Aminobutyric AcidGlutamate DecarboxylaseHomeodomain ProteinsTranscription Factorsforebrain developmentGABAglutamic acid decarboxylasehomeoboxinterneuron

Identifiers

PMID28821666
PMCPMC6596671
OpenAlexW2745263591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.