ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Human Occipital and Parietal GABA Selectively Influence Visual Perception of Orientation and Size.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06234501 (Testing the Potential of High-dose Vitamin B6 Supplements for Sensory Reactivity in Autism), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Testing the Potential of High-dose Vitamin B6 Supplements for Sensory Reactivity in Autism
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Aversively conditioned context enhances visual size illusion via stimulus-specific neural networks.iScience · 2025Article
- Rhythmic beta-frequency TMS over human right parietal cortex strengthens visual size illusions.Psychonomic bulletin & review · 2025Article
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- Major depressive disorder on a neuromorphic continuum.Nature communications · 2025Article
- Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer's disease therapy.Frontiers in pharmacology · 2025Review
- Impaired face symmetry detection under alcohol, but no 'beer goggles' effect.Journal of psychopharmacology (Oxford, England) · 2024Article
- Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study.Frontiers in neuroscience · 2024Article
- Network dynamics underlying alterations in apparent object size.Brain communications · 2024Article
- View Normalization of Object Size in the Right Parietal Cortex.Vision (Basel, Switzerland) · 2022Article
- Neurochemical and functional interactions for improved perceptual decisions through training.Journal of neurophysiology · 2022Article
- Increased cerebral cortex activation in stroke patients during electrical stimulation of cerebellar fastigial nucleus with functional near-infrared spectroscopy.Frontiers in neuroscience · 2022Article
- Estimating How Sounds Modulate Orientation Representation in the Primary Visual Cortex Using Shallow Neural Networks.Frontiers in systems neuroscience · 2022Article
- Effects of the Prolong Life With Nine Turn Method (Yan Nian Jiu Zhuan) Qigong on Brain Functional Changes in Patients With Chronic Fatigue Syndrome in Terms of Fatigue and Quality of Life.Frontiers in neurology · 2022Article
- Functional Interactions between Sensory and Memory Networks for Adaptive Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- The relation between parietal GABA concentration and numerical skills.Scientific reports · 2021Article
- Using psychophysical performance to predict short-term ocular dominance plasticity in human adults.Journal of vision · 2020Article
- A Magnetic Resonance Spectroscopy Study of Superior Visual Search Abilities in Children with Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Real-world size coding of solid objects, but not 2-D or 3-D images, in visual agnosia patients with bilateral ventral lesions.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Learning to optimize perceptual decisions through suppressive interactions in the human brain.Nature communications · 2019Article
- Intra-hemispheric integration underlies perception of tilt illusion.NeuroImage · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
Abstract
GABA is the primary inhibitory neurotransmitter in human brain. The level of GABA varies substantially across individuals, and this variability is associated with interindividual differences in visual perception. However, it remains unclear whether the association between GABA level and visual perception reflects a general influence of visual inhibition or whether the GABA levels of different cortical regions selectively influence perception of different visual features. To address this, we studied how the GABA levels of parietal and occipital cortices related to interindividual differences in size, orientation, and brightness perception. We used visual contextual illusion as a perceptual assay since the illusion dissociates perceptual content from stimulus content and the magnitude of the illusion reflects the effect of visual inhibition. Across individuals, we observed selective correlations between the level of GABA and the magnitude of contextual illusion. Specifically, parietal GABA level correlated with size illusion magnitude but not with orientation or brightness illusion magnitude; in contrast, occipital GABA level correlated with orientation illusion magnitude but not with size or brightness illusion magnitude. Our findings reveal a region- and feature-dependent influence of GABA level on human visual perception. Parietal and occipital cortices contain, respectively, topographic maps of size and orientation preference in which neural responses to stimulus sizes and stimulus orientations are modulated by intraregional lateral connections. We propose that these lateral connections may underlie the selective influence of GABA on visual perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.