ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Location of the Mesopontine Neurons Responsible for Maintenance of Anesthetic Loss of Consciousness.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions.Current neuropharmacology · 2026Review
- Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area.Frontiers in neuroscience · 2025Article
- Neuromodulation with chemicals: Opportunities and challenges.Fundamental research · 2025Review
- Rapid thalamocortical network switching mediated by cortical synchronization underlies propofol-induced EEG signatures: a biophysical model.Journal of neurophysiology · 2023Article
- From molecule to oblivion: dedicated brain circuitry underlies anesthetic loss of consciousness permitting pain-free surgery.Frontiers in molecular neuroscience · 2023Review
- Brain areas modulation in consciousness during sevoflurane anesthesia.Frontiers in integrative neuroscience · 2022Review
- Identifying c-fos Expression as a Strategy to Investigate the Actions of General Anesthetics on the Central Nervous System.Current neuropharmacology · 2022Review
- A Century Searching for the Neurons Necessary for Wakefulness.Frontiers in neuroscience · 2022Review
- A nodal point for brain-state transitions: the mesopontine tegmental anesthesia area (MPTA) in mice.Experimental brain research · 2021Article
- No cognitive processing in the unconscious, anesthetic-like, state of sleep.The Journal of comparative neurology · 2021Review
- Comparison of anaesthetic- and seizure-induced states of unconsciousness: a narrative review.British journal of anaesthesia · 2021Review
- Inactivation of the Ventral Pallidum by GABANeurochemical research · 2020Article
- Manipulating Neural Circuits in Anesthesia Research.Anesthesiology · 2020Review
- The Biology of General Anesthesia from Paramecium to Primate.Current biology : CB · 2019Review
- Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations.Anesthesiology · 2019Review
- Reduced Repertoire of Cortical Microstates and Neuronal Ensembles in Medically Induced Loss of Consciousness.Cell systems · 2019Article
- Using Anesthesia to Reveal the Elements of Consciousness.Trends in cognitive sciences · 2018Article
- Optoanesthesia: Use of Anesthetic Photolabels In Vivo.Methods in enzymology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transition from wakefulness to general anesthesia is widely attributed to suppressive actions of anesthetic molecules distributed by the systemic circulation to the cerebral cortex (for amnesia and loss of consciousness) and to the spinal cord (for atonia and antinociception). An alternative hypothesis proposes that anesthetics act on one or more brainstem or diencephalic nuclei, with suppression of cortex and spinal cord mediated by dedicated axonal pathways. Previously, we documented induction of an anesthesia-like state in rats by microinjection of small amounts of GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.