Evidence map›Paper›PMID 28821618›Full record

ArticleThe Journal of biological chemistry2017

Region-specific protein misfolding cyclic amplification reproduces brain tropism of prion strains.

Nicolas Privat, Etienne Levavasseur, Serfildan Yildirim, Samia Hannaoui, Jean-Philippe Brandel, Jean-Louis Laplanche, Vincent Béringue, Danielle Seilhean, Stéphane Haïk

Abstract read
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In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Prion Strains and Transmission Barrier Phenomena.Pathogens (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicolas PrivatFrom the INSERM, UMR S1127, 75013 Paris, France.
Etienne LevavasseurFrom the INSERM, UMR S1127, 75013 Paris, France.
Serfildan YildirimFrom the INSERM, UMR S1127, 75013 Paris, France.
Samia HannaouiFrom the INSERM, UMR S1127, 75013 Paris, France.
Jean-Philippe BrandelFrom the INSERM, UMR S1127, 75013 Paris, France.
Jean-Louis LaplancheAP-HP, Service de Biochimie et Biologie Moléculaire, Hôpital Lariboisière, 75010 Paris, France.
Vincent BéringueINRA, UR892, 78350 Jouy-en-Josas, France, and.
Danielle SeilheanUPMC, Institut du Cerveau et de la Moelle épinière (ICM), 75013 Paris, France.
Stéphane HaïkFrom the INSERM, UMR S1127, 75013 Paris, France, stephane.haik@upmc.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human prion diseases such as Creutzfeldt-Jakob disease are transmissible brain proteinopathies, characterized by the accumulation of a misfolded isoform of the host cellular prion protein (PrP) in the brain. According to the prion model, prions are defined as proteinaceous infectious particles composed solely of this abnormal isoform of PrP (PrP

Indexed as

Protein FoldingAnimalsBrainCreutzfeldt-Jakob SyndromeHumansMiceMice, TransgenicProtein IsoformsProteostasis DeficienciesPrPSc ProteinsProtein IsoformsPrPSc Proteinsamyloidneurodegenerative diseasePMCAprionprion diseaseprotein aggregationprotein misfoldingregional targetingstrains

Identifiers

PMID28821618
PMCPMC5633130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.