Evidence map›Paper›PMID 28821611›Full record

ArticleThe Journal of biological chemistry2017

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress.

Xiaorong Wang, Ilan E Chemmama, Clinton Yu, Alexander Huszagh, Yue Xu, Rosa Viner, Sarah A Block, Peter Cimermancic, Scott D Rychnovsky, Yihong Ye and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

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  19. Reciprocal REGOxidative medicine and cellular longevity · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Xiaorong WangFrom the Department of Physiology and Biophysics, University of California, Irvine, California 92697.
Ilan E Chemmamathe Departments of Bioengineering and Therapeutic Sciences and Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, University of California, San Francisco, California 94143.
Clinton YuFrom the Department of Physiology and Biophysics, University of California, Irvine, California 92697.
Alexander HuszaghFrom the Department of Physiology and Biophysics, University of California, Irvine, California 92697.
Yue Xuthe Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892.
Rosa VinerThermo Fisher Scientific, San Jose, California 95134, and.
Sarah A Blockthe Department of Chemistry, University of California, Irvine, California 92697.
Peter Cimermancicthe Departments of Bioengineering and Therapeutic Sciences and Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, University of California, San Francisco, California 94143.
Scott D Rychnovskythe Department of Chemistry, University of California, Irvine, California 92697.
Yihong Yethe Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892.
Andrej Salithe Departments of Bioengineering and Therapeutic Sciences and Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, University of California, San Francisco, California 94143.
Lan HuangFrom the Department of Physiology and Biophysics, University of California, Irvine, California 92697, lanhuang@uci.edu.
University of California, Irvine · USUniversity of California, San Francisco · USNational Institutes of Health · USThermo Fisher Scientific (United States) · US

Funding

TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1M
Proteomics of the Proteasome Interacting NetworksR01GM074830 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUANG, LAN · 2005 to 2022
$6.1M
IMP: Software for Hybrid Determination of Macromolecular Assembly StructuresR01GM083960 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 2008 to 2024
$5.2M
How do cells eliminate unassembled cytocolic proteins?ZIADK075144 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI YE, YIHONG · 2017 to 2019
$1.8M
In Vivo Interactome and Dynamics of Cullin-Ring LigasesR01GM106003 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUANG, LAN, RYCHNOVSKY, SCOTT D. · 2013 to 2016
$772k
High Performance Computer for Computational BiosciencesS10OD021596 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 2016 to 2016
$443k
NIGMS NIH HHS P41 GM109824NIGMS NIH HHS R01 GM074830NIGMS NIH HHS R01 GM083960NIGMS NIH HHS R01 GM106003NIGMS NIH HHS T32 GM008284NIH HHS S10 OD021596
6 · The paper itself

Abstract

Oxidative stress has been implicated in multiple human neurological and other disorders. Proteasomes are multi-subunit proteases critical for the removal of oxidatively damaged proteins. To understand stress-associated human pathologies, it is important to uncover the molecular events underlying the regulation of proteasomes upon oxidative stress. To this end, we investigated H

Indexed as

Models, MolecularOxidative StressAdaptor Proteins, Signal TransducingAffinity LabelsATPases Associated with Diverse Cellular ActivitiesCross-Linking ReagentsHEK293 CellsHumansIsotope LabelingLIM Domain ProteinsProteasome Endopeptidase ComplexProtein ConformationProtein Interaction Domains and MotifsProtein Interaction MappingProtein MultimerizationProteolysisAdaptor Proteins, Signal TransducingAffinity LabelsATPases Associated with Diverse Cellular ActivitiesATP dependent 26S proteaseCross-Linking ReagentsECPAS protein, humanLIM Domain ProteinsProteasome Endopeptidase ComplexPSMC5 protein, humanRecombinant Fusion ProteinsTranscription FactorsUbiquitinsUbl4A protein, humanMSoxidative stressproteasomeprotein cross-linkingprotein–protein interactionprotein purificationstructural model

Identifiers

PMID28821611
PMCPMC5625060
OpenAlexW2749756316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.