Evidence map›Paper›PMID 28821610›Full record

ArticleThe Journal of biological chemistry2017

A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the

Adam J Schaenzer, Nathan Wlodarchak, David H Drewry, William J Zuercher, Warren E Rose, Rob Striker, John-Demian Sauer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

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  9. Maintenance of heme homeostasis inJournal of bacteriology · 2023
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  11. Theoretical and Anti-Molecules (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Adam J SchaenzerFrom the Departments of Medical Microbiology and Immunology and.
Nathan WlodarchakFrom the Departments of Medical Microbiology and Immunology and.
David H Drewrythe Structural Genomics Consortium-University of North Carolina at Chapel Hill (SGC-UNC), University of North Carolina at Chapel Hill Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
William J Zuercherthe Structural Genomics Consortium-University of North Carolina at Chapel Hill (SGC-UNC), University of North Carolina at Chapel Hill Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
Warren E RoseMedicine, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Rob StrikerFrom the Departments of Medical Microbiology and Immunology and.
John-Demian SauerFrom the Departments of Medical Microbiology and Immunology and sauer3@wisc.edu.
University of Wisconsin–Madison · USUniversity of North Carolina at Chapel Hill · USWilliam S. Middleton Memorial Veterans Hospital · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Microbial-ecology guided discovery of non-traditional therapeutics that limit resistanceR21AI121704 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KWAN, JASON CHRISTOPHER · 2016 to 2017
$406k
NCATS NIH HHS UL1 TR000427NIAID NIH HHS R21 AI121704Wellcome TrustWellcome Trust 106169/ZZ14/Z
6 · The paper itself

Abstract

Bacterial signaling systems such as protein kinases and quorum sensing have become increasingly attractive targets for the development of novel antimicrobial agents in a time of rising antibiotic resistance. The family of bacterial

Indexed as

Anti-Bacterial AgentsBacterial ProteinsDrug Evaluation, PreclinicalListeria monocytogenesOxadiazolesProtein Kinase InhibitorsProtein Serine-Threonine KinasesStaphylococcus aureusAnti-Bacterial AgentsBacterial ProteinsGSK690693OxadiazolesProtein Kinase InhibitorsProtein Serine-Threonine Kinasesaminofurazansantibioticsbacterial protein kinasebacterial signal transductiondrug discoverydrug screeningListeria monocytogenesPASTA Kinaseβ-lactams

Identifiers

PMID28821610
PMCPMC5641865
OpenAlexW2747823085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.