Evidence map›Paper›PMID 28821607›Full record

ArticleThe Journal of biological chemistry2017

Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis.

Siddharth K Tripathi, Tao Xu, Qin Feng, Bharathi Avula, Xiaomin Shi, Xuewen Pan, Melanie M Mask, Scott R Baerson, Melissa R Jacob, Ranga Rao Ravu and 5 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Antifungal activity of liriodenine on clinical strains ofThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  6. Article
  7. Antifungal activity of liriodenine on agents of systemic mycoses, with emphasis on the genusThe journal of venomous animals and toxins including tropical diseases · 2020
    Article
  8. Article
  9. Article
  10. Promising Antifungal Targets AgainstFrontiers in cellular and infection microbiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Siddharth K TripathiFrom the National Center for Natural Products Research.
Tao XuFrom the National Center for Natural Products Research.
Qin FengFrom the National Center for Natural Products Research.
Bharathi AvulaFrom the National Center for Natural Products Research.
Xiaomin Shithe Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, and.
Xuewen Panthe Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, and.
Melanie M Maskthe United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, University, Mississippi 38677.
Scott R Baersonthe United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, University, Mississippi 38677.
Melissa R JacobFrom the National Center for Natural Products Research.
Ranga Rao RavuFrom the National Center for Natural Products Research.
Shabana I KhanFrom the National Center for Natural Products Research.
Xing-Cong LiFrom the National Center for Natural Products Research.
Ikhlas A KhanFrom the National Center for Natural Products Research.
Alice M ClarkFrom the National Center for Natural Products Research.
Ameeta K AgarwalFrom the National Center for Natural Products Research, aagarwal@olemiss.edu.
Baylor College of Medicine · USUnited States Department of Agriculture · USUniversity of Mississippi · US

Funding

NEW DRUGS FOR OPPORTUNISTIC INFECTIOUS DISEASESR01AI027094 · NIAID · UNIVERSITY OF MISSISSIPPI · PI CLARK, ALICE M. · 1989 to 2013
$4.4M
NIAID NIH HHS R01 AI027094
6 · The paper itself

Abstract

Eupolauridine and liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity against the opportunistic fungal pathogens

Indexed as

Candida albicansFungal ProteinsIron-Sulfur ProteinsMitochondrial ProteinsAntifungal AgentsAporphinesCryptococcus neoformansGenome-Wide Association StudyIndenesNaphthyridinesOxidative StressOxygen ConsumptionSaccharomyces cerevisiaeAntifungal AgentsAporphineseupolauridineFungal ProteinsIndenesIron-Sulfur ProteinsliriodenineMitochondrial ProteinsNaphthyridinesdrug actioninfectious diseaseiron-sulfur proteinsmall moleculeyeast

Identifiers

PMID28821607
PMCPMC5633121
OpenAlexW2748300046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.