ArticlePhysiological reports2017
Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.
Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Self-Feeding Living Materials Enabled by Cell Responsive Glycogen Nanoparticles as Metabolic Batteries.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Anti-Müllerian hormone promotes minichromosome maintenance protein expression and creatine metabolism in primate preantral follicles under hypoxia.Reproductive biology and endocrinology : RB&E · 2026Article
- Proteomics Reveals Mechanisms of Delayed Keratoconus Progression: A Study of Corneas Following Two Light-Activated Crosslinking Treatments.Investigative ophthalmology & visual science · 2025Article
- The Umbilical Cord Creatine Flux and Time Course of Human Milk Creatine across Lactation.Nutrients · 2024Article
- S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by βCellular & molecular biology letters · 2023Article
- Creatine supplementation enhances anti-tumor immunity by promoting adenosine triphosphate production in macrophages.Frontiers in immunology · 2023Article
- Creatine deficiency and heart failure.Heart failure reviews · 2022Review
- Cardiac Oxidative Stress and the Therapeutic Approaches to the Intake of Antioxidant Supplements and Physical Activity.Nutrients · 2021Review
- Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical TrialNutrients · 2021Review
- Role of Creatine in the Heart: Health and Disease.Nutrients · 2021Review
- Kinetic analysis of the transphosphorylation with creatine kinase by pressure-assisted capillary electrophoresis/dynamic frontal analysis.Analytical and bioanalytical chemistry · 2021Article
- Urinary Metabolites as Predictors of Acute Mountain Sickness Severity.Frontiers in physiology · 2021Article
- Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?PeerJ · 2021Article
- Getting an Early Start in Understanding Perinatal Asphyxia Impact on the Cardiovascular System.Frontiers in pediatrics · 2020Review
- AMP-Activated Protein Kinase (AMPK)-Dependent Regulation of Renal Transport.International journal of molecular sciences · 2018Review
- Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.Physiological reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creatine (Cr), phosphocreatine (PCr), and creatine kinases (CK) comprise an energy shuttle linking ATP production in mitochondria with cellular consumption sites. Myocytes cannot synthesize Cr: these cells depend on uptake across the cell membrane by a specialized creatine transporter (CrT) to maintain intracellular Cr levels. Hypoxia interferes with energy metabolism, including the activity of the creatine energy shuttle, and therefore affects intracellular ATP and PCr levels. Here, we report that exposing cultured cardiomyocytes to low oxygen levels rapidly diminishes Cr transport by decreasing
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