ArticleGenetics2017
Accumulation of Deleterious Mutations During Bacterial Range Expansions.
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Nutrient control enables metabolic reconstruction ofbioRxiv : the preprint server for biology · 2026Article
- Spatial structure: shaping the ecology and evolution of microbial communities.FEMS microbiology reviews · 2026Review
- Mutational load and adaptive variation are shaped by climate and species range dynamics in Vitis arizonica.The New phytologist · 2025Article
- Dispersal of influenza virus populations within the respiratory tract shapes their evolutionary potential.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Serial founder effects slow range expansion in an invasive social insect.Nature communications · 2024Article
- Evolution Under Thermal Stress AffectsbioRxiv : the preprint server for biology · 2024Article
- Pleiotropic hubs drive bacterial surface competition through parallel changes in colony composition and expansion.PLoS biology · 2023Article
- Purging due to self-fertilization does not prevent accumulation of expansion load.PLoS genetics · 2023Article
- Allele surfing causes maladaptation in a Pacific salmon of conservation concern.PLoS genetics · 2023Article
- Estimating Temporally Variable Selection Intensity from Ancient DNA Data.Molecular biology and evolution · 2023Article
- Selection in a growing colony biases results of mutation accumulation experiments.Scientific reports · 2022Article
- Exploiting spatial dimensions to enable parallelized continuous directed evolution.Molecular systems biology · 2022Article
- Growth instabilities shape morphology and genetic diversity of microbial colonies.Physical biology · 2022Article
- Gene surfing of underdominant alleles promotes formation of hybrid zones.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Slow expanders invade by forming dented fronts in microbial colonies.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genetic interaction network has a very limited impact on the evolutionary trajectories in continuous culture-grown populations of yeast.BMC ecology and evolution · 2021Article
- Self-selection of evolutionary strategies: adaptiveHeliyon · 2021Article
- Genome evolution and the emergence of pathogenicity in avian Escherichia coli.Nature communications · 2021Article
- Demographic history shaped geographical patterns of deleterious mutation load in a broadly distributed Pacific Salmon.PLoS genetics · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent theory predicts that the fitness of pioneer populations can decline when species expand their range, due to high rates of genetic drift on wave fronts making selection less efficient at purging deleterious variants. To test these predictions, we studied the fate of mutator bacteria expanding their range for 1650 generations on agar plates. In agreement with theory, we find that growth abilities of strains with a high mutation rate (HMR lines) decreased significantly over time, unlike strains with a lower mutation rate (LMR lines) that present three to four times fewer mutations. Estimation of the distribution of fitness effect under a spatially explicit model reveals a mean negative effect for new mutations (-0.38%), but it suggests that both advantageous and deleterious mutations have accumulated during the experiment. Furthermore, the fitness of HMR lines measured in different environments has decreased relative to the ancestor strain, whereas that of LMR lines remained unchanged. Contrastingly, strains with a HMR evolving in a well-mixed environment accumulated less mutations than agar-evolved strains and showed an increased fitness relative to the ancestor. Our results suggest that spatially expanding species are affected by deleterious mutations, leading to a drastic impairment of their evolutionary potential.
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