ArticleGenetics2017
Drift-Induced Selection Between Male and Female Heterogamety.
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Same Sex Chromosomes With Independent Origins in Haplochromine Cichlids.Genome biology and evolution · 2026Article
- Chromosome-specific drift under stabilizing selection generates polygenic barriers to sex chromosome turnover.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- The fourspine stickleback (Apeltes quadracus) has an XY sex chromosome system with polymorphic inversions on both X and Y chromosomes.PLoS genetics · 2025Article
- Sex Chromosome Evolution: Hallmarks and Question Marks.Molecular biology and evolution · 2024Review
- Article
- Divergent evolution of genetic sex determination mechanisms along environmental gradients.Evolution letters · 2023Article
- Article
- Independent Evolution of Sex Chromosomes and Male Pregnancy-Related Genes in Two Seahorse Species.Molecular biology and evolution · 2023Article
- Turnover of multiple sex chromosomes inFrontiers in genetics · 2023Article
- Repeated turnovers keep sex chromosomes young in willows.Genome biology · 2022Article
- Highly rapid and diverse sex chromosome evolution in the Odorrana frog species complex.Development, growth & differentiation · 2022Article
- Something Fishy about Siamese Fighting Fish (Cells · 2022Article
- Dynamics of sex chromosome evolution in a rapid radiation of cichlid fishes.Science advances · 2021Article
- Sex-chromosome evolution in frogs: what role for sex-antagonistic genes?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Establishment of a new sex-determining allele driven by sexually antagonistic selection.G3 (Bethesda, Md.) · 2021Article
- When Sex Chromosomes Recombine Only in the Heterogametic Sex: Heterochiasmy and Heterogamety in Hyla Tree Frogs.Molecular biology and evolution · 2021Article
- Identification of a novel sex determining chromosome in cichlid fishes that acts as XY or ZW in different lineages.Hydrobiologia · 2021Article
- Review
- Sex Chromosome Evolution: So Many Exceptions to the Rules.Genome biology and evolution · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolutionary transitions between male and female heterogamety are common in both vertebrates and invertebrates. Theoretical studies of these transitions have found that, when all genotypes are equally fit, continuous paths of intermediate equilibria link the two sex chromosome systems. This observation has led to a belief that neutral evolution along these paths can drive transitions, and that arbitrarily small fitness differences among sex chromosome genotypes can determine the system to which evolution leads. Here, we study stochastic evolutionary dynamics along these equilibrium paths. We find non-neutrality, both in transitions retaining the ancestral pair of sex chromosomes, and in those creating a new pair. In fact, substitution rates are biased in favor of dominant sex determining chromosomes, which fix with higher probabilities than mutations of no effect. Using diffusion approximations, we show that this non-neutrality is a result of "drift-induced selection" operating at every point along the equilibrium paths: stochastic jumps off the paths return with, on average, a directional bias in favor of the dominant segregating sex chromosome. Our results offer a novel explanation for the observed preponderance of dominant sex determining genes, and hint that drift-induced selection may be a common force in standard population genetic systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.