Evidence map›Paper›PMID 28821425›Full record

ReviewArchives of biochemistry and biophysics2017

Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.

Kalani Karunaratne, Nicholas Luedtke, Daniel M Quinn, Amnon Kohen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Archives of biochemistry and biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. [Expression of thymidylate synthase in salivary adenoid myoepithelial cells and its clinical significance].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kalani KarunaratneDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
Nicholas LuedtkeDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
Daniel M QuinnDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, USA. Electronic address: daniel-quinn@uiowa.edu.
Amnon KohenDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
University of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
PREDOCTORAL TRAINING PROGRAM IN BIOTECHNOLOGYT32GM008365 · NIGMS · UNIVERSITY OF IOWA · PI KERNS, ROBERT JOHN · 1990 to 2021
$3.8M
Mechanistic Studies of Flavin Dependent Thymidylate SynthaseR01GM110775 · NIGMS · UNIVERSITY OF IOWA · PI QUINN, DANIEL M · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM110775NIGMS NIH HHS T32 GM008365
6 · The paper itself

Abstract

Thymidylate is synthesized de novo in all living organisms for replication of genomes. The chemical transformation is reductive methylation of deoxyuridylate at C5 to form deoxythymidylate. All eukaryotes including humans complete this well-understood transformation with thymidylate synthase utilizing 6R-N

Indexed as

FlavinsFlavoproteinsMethylationTetrahydrofolatesThymidine MonophosphateThymidylate Synthase5,10-methenyltetrahydrofolateFlavinsFlavoproteinsTetrahydrofolatesThymidine MonophosphateThymidylate SynthaseEnzymeFlavinMechanismsN5-flavin adductThymidylateThymidylate synthase

Identifiers

PMID28821425
PMCPMC5728703
OpenAlexW2746076072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.