Evidence map›Paper›PMID 28821301›Full record

ArticleMicrobiome2017

Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome.

David Casero, Kirandeep Gill, Vijayalakshmi Sridharan, Igor Koturbash, Gregory Nelson, Martin Hauer-Jensen, Marjan Boerma, Jonathan Braun, Amrita K Cheema

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David CaseroDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Kirandeep GillDepartment of Oncology, Georgetown University Medical Center, Washington DC, 20057, USA.
Vijayalakshmi SridharanDivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Igor KoturbashDepartment of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Gregory NelsonDepartment of Radiation Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
Martin Hauer-JensenDivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Marjan BoermaDivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Jonathan BraunDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Amrita K CheemaDepartment of Oncology, Georgetown University Medical Center, Washington DC, 20057, USA. akc27@georgetown.edu.

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1M
The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI WOLFE, TATIANA · 2015 to 2024
$21.1M
NCI NIH HHS P30 CA051008NIDDK NIH HHS P01 DK046763NIGMS NIH HHS P20 GM109005
6 · The paper itself

Abstract

backgroundSpace travel is associated with continuous low dose rate exposure to high linear energy transfer (LET) radiation. Pathophysiological manifestations after low dose radiation exposure are strongly influenced by non-cytocidal radiation effects, including changes in the microbiome and host gene expression. Although the importance of the gut microbiome in the maintenance of human health is well established, little is known about the role of radiation in altering the microbiome during deep-space travel.

resultsUsing a mouse model for exposure to high LET radiation, we observed substantial changes in the composition and functional potential of the gut microbiome. These were accompanied by changes in the abundance of multiple metabolites, which were related to the enzymatic activity of the predicted metagenome by means of metabolic network modeling. There was a complex dynamic in microbial and metabolic composition at different radiation doses, suggestive of transient, dose-dependent interactions between microbial ecology and signals from the host's cellular damage repair processes. The observed radiation-induced changes in microbiota diversity and composition were analyzed at the functional level. A constitutive change in activity was found for several pathways dominated by microbiome-specific enzymatic reactions like carbohydrate digestion and absorption and lipopolysaccharide biosynthesis, while the activity in other radiation-responsive pathways like phosphatidylinositol signaling could be linked to dose-dependent changes in the abundance of specific taxa.

conclusionsThe implication of microbiome-mediated pathophysiology after low dose ionizing radiation may be an unappreciated biologic hazard of space travel and deserves experimental validation. This study provides a conceptual and analytical basis of further investigations to increase our understanding of the chronic effects of space radiation on human health, and points to potential new targets for intervention in adverse radiation effects.

Indexed as

Radiation, IonizingAnimalsCarbohydrate MetabolismGastrointestinal MicrobiomeHumansLinear Energy TransferLipopolysaccharidesMetabolic Networks and PathwaysMetabolomeMetagenomeMiceObesityLipopolysaccharides16S rRNA amplicon sequencingIonizing radiationMetabolic network modelingMicrobiomeSpace travelUntargeted metabolomics

Identifiers

PMID28821301
PMCPMC5563039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.